Effect of Alpha-1 Antitrypsin and Irisin on Post-Exercise Inflammatory Response: A Narrative Review

Iran J Med Sci. 2024 Apr 1;49(4):205-218. doi: 10.30476/IJMS.2023.97480.2925. eCollection 2024 Apr.

Abstract

Physical activity has a positive effect on human health and emotional well-being. However, in both amateur and professional athletes, training poses a risk of acute or chronic injury through repetitive overloading of bones, joints, and muscles. Inflammation can be an adverse effect of intense exercise caused by several factors including oxidative stress. The present narrative review summarizes current knowledge on inflammatory markers induced by physical exercise. Post-exercise recovery may reduce inflammatory responses and is key to effective training and adaptation of muscle tissues to sustained physical exertion.

Keywords: Exercise; Inflammation; Oxidative stress; Serine proteinase inhibitors.

Publication types

  • Review

MeSH terms

  • Exercise* / physiology
  • Exercise* / psychology
  • Fibronectins* / blood
  • Humans
  • Inflammation*
  • alpha 1-Antitrypsin* / blood

Substances

  • Fibronectins
  • alpha 1-Antitrypsin
  • FNDC5 protein, human