Stability analysis and numerical evaluations of a COVID-19 model with vaccination

BMC Med Res Methodol. 2024 Apr 27;24(1):97. doi: 10.1186/s12874-024-02209-2.

Abstract

A novel (nonlinear) mathematical model for the transmission of Coronavirus 19 (COVID-19) with eight compartments and considering the impact of vaccination is examined in this manuscript. The qualitative behavior of the system such as the boundedness of solutions, the basic reproduction number, and the stability of the equilibrium points is investigated in detail. Some domestic real data collected from the Kerman University of Medical Science (KUMC) is used to estimate the parameters of the proposed model. We predict the dynamical behavior of the system through numerical simulations based on a combined spectral matrix collocation methodology. In this respect, we first linearize the nonlinear system of equations by the method of quasilinearization (QLM). Hence, the shifted version of Chebyshev polynomials of the second kind (SCPSK) is utilized along with the domain-splitting strategy to acquire the solutions of the system over a long time interval. The uniform convergence and upper bound estimation of the SCPSK bases are proved in a rigorous manner. Moreover, the technique of residual error functions is used to testify the accuracy of the QLM-SCPSK method. The presented numerical results justify the robustness and good accuracy of the QLM-SCPSK technique. The achieved numerical orders of convergence indicate that the QLM-SCSK algorithm has exponential rate of convergence. Using the linearization technique in one hand and the domain-splitting strategy on the other hand, enable us to predict the behaviour of similar disease problems with high accuracy and maximum efficiency on an arbitrary domain of interest.

Keywords: COVID-19 model; Chebyshev functions; Collocation points; Convergent analysis; Stability analysis.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Algorithms
  • Basic Reproduction Number / statistics & numerical data
  • COVID-19 Vaccines*
  • COVID-19* / prevention & control
  • COVID-19* / transmission
  • Computer Simulation
  • Humans
  • Models, Theoretical
  • Nonlinear Dynamics
  • SARS-CoV-2* / immunology
  • Vaccination* / methods
  • Vaccination* / statistics & numerical data

Substances

  • COVID-19 Vaccines