Treatment of Central Precocious Puberty with a Focus on Girls

Abstract

The age of thelarche has declined in the past few decades but not the age of menarche. This is important when assessing girls who present with breast development between 6 and 8 years because not all of them will need treatment. The decision for treatment depends on age, bone age (BA), rate of pubertal progression, height velocity, psychosocial factors, and predicted adult height (PAH), with the caveat that height predictions are not precise and BA interpretation is variable.

Keywords: Bone age; Central precocious puberty; Gonadotropin-releasing hormone analog (GnRHa); Precocious puberty; Predicted adult height.