Blending polydopamine-derived imprinted polymers with rice straw-based fluorescent carbon dots for selective detection and adsorptive removal of ibuprofen

Irshad Mohiuddin; Raghubir Singh; Varinder Kaur

doi:10.1016/j.ijbiomac.2024.131765

Blending polydopamine-derived imprinted polymers with rice straw-based fluorescent carbon dots for selective detection and adsorptive removal of ibuprofen

Int J Biol Macromol. 2024 Apr 25;269(Pt 1):131765. doi: 10.1016/j.ijbiomac.2024.131765. Online ahead of print.

Authors

Irshad Mohiuddin¹, Raghubir Singh², Varinder Kaur³

Affiliations

¹ Department of Chemistry, Panjab University, Sector-14, Chandigarh 160014, India. Electronic address: irshad@pu.ac.in.
² Department of Chemistry, DAV College, Sector, 10, Chandigarh, -160011, India.
³ Department of Chemistry, Panjab University, Sector-14, Chandigarh 160014, India. Electronic address: var_ka04@pu.ac.in.

PMID: 38677686
DOI: 10.1016/j.ijbiomac.2024.131765

Abstract

Dual-functioning probes capable of detecting and removing hazardous substances have recently received increased attention compared to exclusive sensory probes. Herein, a new composite is synthesized by blending polydopamine imprinted polymers with fluorescent carbon dots (PIP-FCDs) for the selective recognition and adsorption of Ibuprofen (IBF). IBF is a nonsteroidal anti-inflammatory drug and is excessively released in the pharmaceutical wastes. The PIP-FCDs consist of confined pockets for encasing IBF and quenches fluorescence signal when contact with the molecule. PIP-FCDs show high sensitivity (limit of detection = 1.58 × 10^-5 μM) and selectivity towards IBF in the presence of other pharmaceutical drugs i.e., aspirin, ketoprofen, norfloxacin, and levofloxacin. The adsorption studies show an adsorption capacity of 209.8 mg g^-1 with an extraction efficiency of around 99.9 %. Furthermore, PIP-FCDs are utilized to determine IBF levels in various aqueous pharmaceutical samples. This development provides a simple and dual-functioning probe for the detection and adsorption of IBF from various matrices.

Keywords: Adsorption; Dopamine; Fluorescent carbon dots; Ibuprofen; Molecularly imprinting polymers.