Patient-Derived Xenograft Models for Ovarian Cancer

Trang Minh Tran; Gwo Yaw Ho; Simon Chu

doi:10.1007/978-1-0716-3858-3_13

Patient-Derived Xenograft Models for Ovarian Cancer

Methods Mol Biol. 2024:2806:187-196. doi: 10.1007/978-1-0716-3858-3_13.

Authors

Trang Minh Tran^{1

2}, Gwo Yaw Ho^{2

3}, Simon Chu⁴

Affiliations

¹ Hudson Institute of Medical Research, Clayton, VIC, Australia.
² School of Clinical Sciences, Monash University, Clayton, VIC, Australia.
³ Monash Health, Clayton, VIC, Australia.
⁴ Hudson Institute of Medical Research, Clayton, VIC, Australia. Simon.chu@hudson.org.au.

PMID: 38676803
DOI: 10.1007/978-1-0716-3858-3_13

Abstract

Patient-derived xenograft (PDX) models play a crucial role for in vivo research. They maintain the original molecular characteristics of the human tumor and provide a more accurate tumor microenvironment, which cannot be replicated by in vitro models. This chapter describes four different transplantation methods, namely, intra-bursal, intrarenal capsule, intraperitoneal, and subcutaneous, to develop PDX models for ovarian cancer research.

Keywords: Intra-bursal; Intraperitoneal; Intrarenal capsule; Ovarian cancer; Patient-derived xenograft (PDX); Subcutaneous.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Animals
Disease Models, Animal*
Female
Heterografts
Humans
Mice
Ovarian Neoplasms* / pathology
Tumor Microenvironment
Xenograft Model Antitumor Assays* / methods