Patient-Derived Xenografts: Historical Evolution, Immunocompromised Host Models, and Translational Significance

Abstract

Patient-derived xenografts (PDXs) represent a critical advancement in preclinical cancer research, wherein human tumor samples are implanted into animal models for evaluation of therapeutic responses. PDXs have emerged as indispensable tools in translational cancer research, facilitating investigation into tumor microenvironments and personalized medicine. This chapter elucidates the historical evolution of PDXs, from early attempts in the eighteenth century to contemporary immunocompromised host models that enhance engraftment success.

Keywords: Orthoxenografts; Patient-derived xenografts (PDXs); Preclinical models; Translational cancer research.