Vitamin D and Dyslipidemia: Is There Really a Link? A Narrative Review

Nutrients. 2024 Apr 12;16(8):1144. doi: 10.3390/nu16081144.

Abstract

Nowadays, the interest in the extraskeletal effects of vitamin D is growing. In the literature, its several possible actions have been confirmed. Vitamin D seems to have a regulatory role in many different fields-inflammation, immunity, and the endocrine system-and many studies would demonstrate a possible correlation between vitamin D and cardiovascular disease. In this paper, we deepened the relationship between vitamin D and dyslipidemia by reviewing the available literature. The results are not entirely clear-cut: on the one hand, numerous observational studies suggest a link between higher serum vitamin D levels and a beneficial lipid profile, while on the other hand, interventional studies do not demonstrate a significant effect. Understanding the possible relationship between vitamin D and dyslipidemia may represent a turning point: another link between vitamin D and the cardiovascular system.

Keywords: cardiovascular prevention; cholesterol; dyslipidemia; triglycerides; vitamin D.

Publication types

  • Review

MeSH terms

  • Cardiovascular Diseases / etiology
  • Cardiovascular Diseases / prevention & control
  • Dyslipidemias* / blood
  • Humans
  • Lipids / blood
  • Vitamin D Deficiency* / blood
  • Vitamin D Deficiency* / complications
  • Vitamin D* / blood

Substances

  • Vitamin D
  • Lipids

Grants and funding

This research received no external funding.