Nutritional Support: The Use of Antioxidants in Inflammatory Bowel Disease

Int J Mol Sci. 2024 Apr 16;25(8):4390. doi: 10.3390/ijms25084390.

Abstract

The problem of treating inflammatory bowel disease continues to be a topic of great interest for researchers. Despite the complexity surrounding their treatment and strategies to prolong periods of remission, there is a promising exploration of various compounds that have potential in combating inflammation and alleviating symptoms. Selenium, calcium, magnesium, zinc, and iron are among these compounds, offering a glimpse of hope in the treatment of IBD. These essential minerals not only hold the promise of reducing inflammation in these diseases, but also show the potential to enhance immune function and possibly influence the balance of intestinal microflora. By potentially modulating the gut microbiota, they may help support overall immune health. Furthermore, these compounds could play a crucial role in mitigating inflammation and minimising complications in patients with IBD. Furthermore, the protective effect of these compounds against mucosal damage in IBD and the protective effect of calcium itself against osteoporosis in this group of patients are notable.

Keywords: Crohn’s disease; antioxidants; inflammatory bowel diseases; minerals; ulcerative colitis.

Publication types

  • Review

MeSH terms

  • Animals
  • Antioxidants* / pharmacology
  • Antioxidants* / therapeutic use
  • Calcium / metabolism
  • Dietary Supplements
  • Gastrointestinal Microbiome* / drug effects
  • Humans
  • Inflammatory Bowel Diseases* / drug therapy
  • Magnesium / therapeutic use
  • Nutritional Support / methods
  • Selenium / pharmacology
  • Selenium / therapeutic use
  • Zinc / therapeutic use

Substances

  • Antioxidants
  • Selenium
  • Magnesium
  • Zinc
  • Calcium

Grants and funding

This research received no external funding.