On Interactions of Sulfamerazine with Cyclodextrins from Coupled Diffusometry and Toxicity Tests

Biomolecules. 2024 Apr 10;14(4):462. doi: 10.3390/biom14040462.

Abstract

This scientific study employs the Taylor dispersion technique for diffusion measurements to investigate the interaction between sulfamerazine (NaSMR) and macromolecular cyclodextrins (β-CD and HP-β-CD). The results reveal that the presence of β-CD influences the diffusion of the solution component, NaSMR, indicating a counterflow of this drug due to solute interaction. However, diffusion data indicate no inclusion of NaSMR within the sterically hindered HP-β-CD cavity. Additionally, toxicity tests were conducted, including pollen germination (Actinidia deliciosa) and growth curve assays in BY-2 cells. The pollen germination tests demonstrate a reduction in sulfamerazine toxicity, suggesting potential applications for this antimicrobial agent with diminished adverse effects. This comprehensive investigation contributes to a deeper understanding of sulfamerazine-cyclodextrin interactions and their implications for pharmaceutical and biological systems.

Keywords: antibiotics; cyclodextrins; diffusion; sulfamerazine; toxicity tests; transport properties.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • 2-Hydroxypropyl-beta-cyclodextrin / chemistry
  • Cyclodextrins / chemistry
  • Diffusion
  • Sulfamerazine* / chemistry
  • Toxicity Tests
  • beta-Cyclodextrins / chemistry

Substances

  • Sulfamerazine
  • Cyclodextrins
  • beta-Cyclodextrins
  • 2-Hydroxypropyl-beta-cyclodextrin

Grants and funding

The authors are grateful for funding from the Coimbra Chemistry Centre, which is supported by the Fundação para a Ciência e a Tecnologia (FCT), Portuguese Agency for Scientific Research, through the projects UID/QUI/UI0313/2013 and COMPETE Programme (Operational Programme for Competitiveness).