A prospective cohort study of exposure to household pesticide with cardiovascular diseases mortality in older adults

Xiyao Zhao; Jiayuan Li; Yongqi Liu; Yunjie Liu; Xia Jiang; Lu Long; Jintao Wang; Yuqing Yao; Qin Zhang; Ming Li; Xiaomeng Li; Ben Zhang; Jiaqiang Liao

doi:10.1016/j.jhazmat.2024.134316

A prospective cohort study of exposure to household pesticide with cardiovascular diseases mortality in older adults

J Hazard Mater. 2024 Apr 21:471:134316. doi: 10.1016/j.jhazmat.2024.134316. Online ahead of print.

Authors

Xiyao Zhao¹, Jiayuan Li², Yongqi Liu¹, Yunjie Liu², Xia Jiang³, Lu Long², Jintao Wang⁴, Yuqing Yao⁵, Qin Zhang⁵, Ming Li⁶, Xiaomeng Li⁶, Ben Zhang⁷, Jiaqiang Liao⁸

Affiliations

¹ Department of Epidemiology and Health Statistics, West China School of Public Health and West China Fourth Hospital, Sichuan University, Chengdu, Sichuan, 610041, China; Department of Systematic Epidemiology, West China School of Public Health and West China Fourth Hospital, Sichuan University, Chengdu, Sichuan, 610041, China; Research Center for Prevention and Therapy of Occupational Diseases, West China-PUMC C.C. Chen Institute of Health, Sichuan University, Chengdu, Sichuan, 610041, China; Department of Occupational and Environmental Health, West China School of Public Health and West China Fourth Hospital, Sichuan University, Chengdu, Sichuan, 610041, China.
² Department of Epidemiology and Health Statistics, West China School of Public Health and West China Fourth Hospital, Sichuan University, Chengdu, Sichuan, 610041, China; Department of Systematic Epidemiology, West China School of Public Health and West China Fourth Hospital, Sichuan University, Chengdu, Sichuan, 610041, China.
³ Department of Epidemiology and Health Statistics, West China School of Public Health and West China Fourth Hospital, Sichuan University, Chengdu, Sichuan, 610041, China; Department of Systematic Epidemiology, West China School of Public Health and West China Fourth Hospital, Sichuan University, Chengdu, Sichuan, 610041, China; Department of Nutrition and Food Hygiene, West China School of Public Health and West China Fourth Hospital, Sichuan University, Chengdu, Sichuan, 610041, China.
⁴ Department of Occupational and Environmental Health, West China School of Public Health and West China Fourth Hospital, Sichuan University, Chengdu, Sichuan, 610041, China.
⁵ Department of Systematic Epidemiology, West China School of Public Health and West China Fourth Hospital, Sichuan University, Chengdu, Sichuan, 610041, China; Research Center for Prevention and Therapy of Occupational Diseases, West China-PUMC C.C. Chen Institute of Health, Sichuan University, Chengdu, Sichuan, 610041, China; Department of Occupational and Environmental Health, West China School of Public Health and West China Fourth Hospital, Sichuan University, Chengdu, Sichuan, 610041, China.
⁶ Department of Systematic Epidemiology, West China School of Public Health and West China Fourth Hospital, Sichuan University, Chengdu, Sichuan, 610041, China; Department of Nutrition and Food Hygiene, West China School of Public Health and West China Fourth Hospital, Sichuan University, Chengdu, Sichuan, 610041, China.
⁷ Department of Epidemiology and Health Statistics, West China School of Public Health and West China Fourth Hospital, Sichuan University, Chengdu, Sichuan, 610041, China; Department of Systematic Epidemiology, West China School of Public Health and West China Fourth Hospital, Sichuan University, Chengdu, Sichuan, 610041, China; Department of Occupational and Environmental Health, West China School of Public Health and West China Fourth Hospital, Sichuan University, Chengdu, Sichuan, 610041, China.
⁸ Department of Epidemiology and Health Statistics, West China School of Public Health and West China Fourth Hospital, Sichuan University, Chengdu, Sichuan, 610041, China; Department of Systematic Epidemiology, West China School of Public Health and West China Fourth Hospital, Sichuan University, Chengdu, Sichuan, 610041, China; Research Center for Prevention and Therapy of Occupational Diseases, West China-PUMC C.C. Chen Institute of Health, Sichuan University, Chengdu, Sichuan, 610041, China. Electronic address: ljq19861023@163.com.

PMID: 38669923
DOI: 10.1016/j.jhazmat.2024.134316

Abstract

Objectives: We examined the associations of self-reported exposures, and urinary metabolites related to household pesticide with cardiovascular disease (CVD) mortality in older adults based on the 2007 to 2014 waves of National Health and Nutrition Examination Survey (NHANES).

Methods: Information on application and urinary metabolites related to household pesticide exposure were collected. We estimated the risks of household pesticide exposure, urinary metabolites with subsequent incident CVD death using Cox proportional hazards regression models. The indirect effects of urinary metabolites and effect modifications were examined.

Results: The participants who reported exposure to household pesticide had a higher risk of incident CVD death (adjusted HR 1.40, 95% CI 1.08 to 1.81). Per 1-log10 increase in urinary N, N-diethyl-3-methylbenzamide (DEET) related to household insect repellents was associated with a higher risk of incident CVD death (adjusted HR 1.97, 95% CI 1.14 to 3.40). Urinary DEET explained 4.21% of the total association between household pesticide exposure and CVD death risk. The participants who persisted a low level of health diet exhibited pronounced CVD death risks with household pesticide exposures.

Conclusions: Exposure to household pesticide, especially household insect repellents, was consistently associated with an elevated CVD death risk in older adults. A heatlhy diet could partly attenuate the associations.

Keywords: Cardiovascular diseases; Household pesticide; Older adults; Prospective cohort.