Association of anemia with all-cause mortality in Chinese centenarians: a prospective cohort study

Wangping Jia; Shengshu Wang; Shanshan Yang; Yali Zhao; Qiao Zhu; Chaoxue Ning; Yujian Chen; Shihui Fu; Yizhi Chen; Yao He; Miao Liu

doi:10.1016/j.jnha.2024.100248

Association of anemia with all-cause mortality in Chinese centenarians: a prospective cohort study

J Nutr Health Aging. 2024 Apr 25;28(7):100248. doi: 10.1016/j.jnha.2024.100248. Online ahead of print.

Authors

Wangping Jia¹, Shengshu Wang², Shanshan Yang³, Yali Zhao⁴, Qiao Zhu⁴, Chaoxue Ning⁴, Yujian Chen⁴, Shihui Fu⁵, Yizhi Chen⁶, Yao He⁷, Miao Liu⁸

Affiliations

¹ Department of Wound Infection and Drug, Daping Hospital, Army Medical University, Chongqing 400042, China.
² Institute of Geriatrics, Beijing Key Laboratory of Aging and Geriatrics, National Clinical Research Center for Geriatric Diseases, Second Medical Center, State Key Laboratory of Kidney Diseases, Chinese People's Liberation Army General Hospital, Beijing 100853, China.
³ Department of Disease Prevention and Control, First Medical Center, Chinese People's Liberation Army General Hospital, Beijing 100853, China.
⁴ Central Laboratory, Hainan Hospital of Chinese People's Liberation Army General Hospital, Sanya 572013, China.
⁵ Department of Cardiology, Hainan Hospital of Chinese People's Liberation Army General Hospital, Sanya 572013, China.
⁶ Department of Nephrology, Hainan Hospital of Chinese PLA General Hospital, Academician Chen Xiangmei of Hainan Province Kidney Diseases Research Team Innovation Center, Sanya 572013, China; Senior Department of Nephrology, The First Medical Center of Chinese PLA General Hospital, Chinese PLA Institute of Nephrology, State Key Laboratory of Kidney Diseases, National Clinical Research Center for Kidney Diseases, Beijing Key Laboratory of Kidney Diseases Research, Beijing 100853, China.
⁷ Institute of Geriatrics, Beijing Key Laboratory of Aging and Geriatrics, National Clinical Research Center for Geriatric Diseases, Second Medical Center, State Key Laboratory of Kidney Diseases, Chinese People's Liberation Army General Hospital, Beijing 100853, China. Electronic address: yhe301@x263.net.
⁸ Institute of Geriatrics, Beijing Key Laboratory of Aging and Geriatrics, National Clinical Research Center for Geriatric Diseases, Second Medical Center, State Key Laboratory of Kidney Diseases, Chinese People's Liberation Army General Hospital, Beijing 100853, China; Department of Anti-NBC Medicine, Graduate School, Chinese People's Liberation Army General Hospital, Beijing 100853, China. Electronic address: liumiaolmbxb@163.com.

PMID: 38669839
DOI: 10.1016/j.jnha.2024.100248

Abstract

Objectives: This study aimed to examine the relationship between anemia and all-cause mortality in Chinese centenarians.

Design: Prospective cohort study.

Setting and participants: We included 1002 Chinese centenarians from the China Hainan Centenarian Cohort Study (CHCCS) MEASUREMENTS: Standard procedures were followed to perform blood analysis, home interviews, and physical examinations. Anemia was defined as a hemoglobin level of less than 130 g/L for men and less than 120 g/L for women.

Results: During the 9-year follow-up period, a total of 929 (92.7%) deaths were identified. Cox proportional hazards regression models revealed that anemia (hazard ratio [HR] 1.289, 95% confidence interval [CI]: 1.117-1.489) was significantly associated with all-cause mortality. There was an apparent dose-response relationship between anemia and all-cause mortality. Centenarians with severe anemia had approximately 1.6 times higher likelihood of all-cause mortality than those without anemia (HR 1.662; 95% CI: 1.154-2.394).

Conclusion: Anemia is associated with an increased risk of all-cause mortality in Chinese centenarians. Further research will be needed to collect more comprehensive data on the etiology of anemia and causes of death in centenarians.

Keywords: All-cause mortality; Anemia; Chinese centenarians; Hemoglobin.