Increased risk of preterm birth due to heat exposure during pregnancy: Exploring the mechanism of fetal physiology

Liyun Wang; Chunying Zhang; Jiangli Di; Qiong Wang; Meng Ren; Aiqun Huang; Sidi Chen; Wei Zhao; Huanqing Hu; Ailing Wang; Qian Di; John S Ji; Wannian Liang; Cunrui Huang

doi:10.1016/j.scitotenv.2024.172730

Increased risk of preterm birth due to heat exposure during pregnancy: Exploring the mechanism of fetal physiology

Sci Total Environ. 2024 Apr 23:931:172730. doi: 10.1016/j.scitotenv.2024.172730. Online ahead of print.

Authors

Liyun Wang¹, Chunying Zhang², Jiangli Di², Qiong Wang¹, Meng Ren¹, Aiqun Huang², Sidi Chen², Wei Zhao², Huanqing Hu², Ailing Wang³, Qian Di⁴, John S Ji⁴, Wannian Liang⁵, Cunrui Huang⁶

Affiliations

¹ School of Public Health, Sun Yat-sen University, Guangzhou, China.
² National Center for Women and Children's Health, Chinese Center for Disease Control and Prevention, Beijing, China.
³ National Center for Women and Children's Health, Chinese Center for Disease Control and Prevention, Beijing, China. Electronic address: ailing@chinawch.org.cn.
⁴ Vanke School of Public Health, Tsinghua University, Beijing, China.
⁵ Vanke School of Public Health, Tsinghua University, Beijing, China; Institute of Healthy China, Tsinghua University, Beijing, China.
⁶ Vanke School of Public Health, Tsinghua University, Beijing, China; Institute of Healthy China, Tsinghua University, Beijing, China. Electronic address: huangcunrui@tsinghua.edu.cn.

PMID: 38663596
DOI: 10.1016/j.scitotenv.2024.172730

Abstract

Background: Heat exposure during pregnancy can increase the risk of preterm birth (PTB) through a range of potential mechanisms including pregnancy complications, hormone secretion and infections. However, current research mainly focuses on the effect of heat exposure on pathophysiological pathways of pregnant women, but ignore that maternal heat exposure can also cause physiological changes to the fetus, which will affect the risk of PTB.

Objective: In this study, we aimed to explore the mediating role of fetal heart rate (FHR) in the relationship between maternal heat exposure and PTB incidence.

Methods: We assigned heat exposure to a multi-center birth cohort in China during 2015-2018, which included all 162,407 singleton live births with several times FHR measurements during the second and third trimesters. We examined the associations between heat exposure, FHR and PTB in the entire pregnancy, each trimester and the last gestational month. The inverse odds ratio-weighted approach applied to the Cox regression was used to identify the mediation effect of heat exposure on PTB and its clinical subtypes via FHR.

Findings: Exposure to heat significantly increased the risk of PTB during the third trimester and the entire pregnancy, hazard ratios and 95 % CIs were 1.266 (1.161, 1.379) and 1.328 (1.218, 1.447). Heat exposure during the third trimester and entire pregnancy increased FHR in the third trimester by 0.24 bpm and 0.14 bpm. The proportion of heat exposure mediated by FHR elevation on PTB and its subtype ranged from 3.68 % to 24.06 %, with the significant mediation effect found for both medically indicated PTB and spontaneous PTB.

Conclusions: This study suggests that heat exposure during pregnancy has an important impact on fetal health, and FHR, as a surrogate marker of fetal physiology, may mediate the increased risk of PTB caused by extreme heat. Monitoring and managing physiological changes in the fetus would constitute a promising avenue to reduce adverse birth outcomes associated with maternal heat exposure.

Keywords: Climate change; Fetal heart rate; Heat exposure; Mediation effect; Preterm birth.