Hemophagocytic lymphohistiocytosis associated with brucellosis

Mingjing Guo; Liqun Zhang; Kui Chen; Dezhi Huang; Chunfeng Feng; Hongyun Liu; Nian Quan; Fanfei Meng; Xiaojuan Deng; Fei Liu

doi:10.1016/j.diagmicrobio.2024.116289

Hemophagocytic lymphohistiocytosis associated with brucellosis

Diagn Microbiol Infect Dis. 2024 Mar 28;109(3):116289. doi: 10.1016/j.diagmicrobio.2024.116289. Online ahead of print.

Authors

Affiliations

¹ Department of Clinical Laboratory, Xinqiao Hospital, Army Medical University, Chongqing, 400037, China.
² Medical center of Hematology, Xinqiao Hospital, Key Laboratory of Trauma and Chemical Poisoning, Army Medical University, Chongqing, 400037, China.
³ Department of Clinical Laboratory, Xinqiao Hospital, Army Medical University, Chongqing, 400037, China. Electronic address: susufei@sina.com.

PMID: 38663334
DOI: 10.1016/j.diagmicrobio.2024.116289

Abstract

Hemophagocytic lymphohistiocytosis (HLH) is a life-threatening immune disorder categorized as familial HLH or secondary HLH. Our case report describes a 63-year-old woman with epilepsy whose clinical signs were unremitting fever and altered consciousness. Primary abnormalities consisted of fever, splenomegaly, cytopenia, hypertriglyceridemia, hyperferritinemia and hemophagocytosis in the bone marrow. Results of blood next generation sequencing and blood culture confirmed Brucella infection. This report illustrates a sHLH case caused by Brucella melitensis infection. Here, we review the classification, clinical features, diagnostic methods, treatment regimens, differential diagnosis, and prognosis of HLH and brucellosis.

Keywords: Adult; Brucella melitensis; Brucellosis; HLH; Infection.

Publication types

Case Reports