Mn(II) Coordination Complex Loaded Hydrogel: Synthesis, Characterization, Fluorescence Properties, and Application in Treating Knee Arthritis

Hongpeng Liu; Xiaodong Li; Pengfei Li; Xiangjun Yang; Yongji Li; Hanbing Song

doi:10.1007/s10895-024-03722-9

Mn(II) Coordination Complex Loaded Hydrogel: Synthesis, Characterization, Fluorescence Properties, and Application in Treating Knee Arthritis

J Fluoresc. 2024 Apr 25. doi: 10.1007/s10895-024-03722-9. Online ahead of print.

Authors

Hongpeng Liu^#¹, Xiaodong Li^#², Pengfei Li³, Xiangjun Yang⁴, Yongji Li⁴, Hanbing Song⁵

Affiliations

¹ Orthopedics and Traumatology Department, Heilongjiang University of Chinese Medicine/The Second Affiliated Hospital of Heilongjiang University of Chinese Medicine, Harbin, Heilongjiang, China.
² Orthopedics and Traumatology Department, The Third Affiliated Hospital of Heilongjiang University of Chinese Medicine, Harbin, Heilongjiang, China.
³ Orthopedics and Traumatology Department, The Second Affiliated Hospital of Heilongjiang University of Chinese Medicine, Harbin, Heilongjiang, China.
⁴ Orthopedics and Traumatology Department, Hanan Branch of the Second Affiliated Hospital of Heilongjiang University of Traditional Chinese Medicine, Harbin, Heilongjiang, China.
⁵ Orthopedics and Traumatology Department, Heilongjiang University of Chinese Medicine/The First Affiliated Hospital of Heilongjiang University of Chinese Medicine, Harbin, Heilongjiang, China. songhanbing@hljucm.net.

^# Contributed equally.

PMID: 38662254
DOI: 10.1007/s10895-024-03722-9

Abstract

Using a mixed-ligand approach, we successfully obtained two Mn(II)-based coordination compounds, namely [Mn₂(L1)(TBIP)·H₂O]n (1) and [Mn₂(L2)(NPTA)·H₂O]n (2) (where L1 and L2 are 1,4-bis(thiabenzimidazol-1-ylmethyl)benzene and 1,2-bis(thiabenzimidazol-1-ylmethyl)benzene, H₂NPTA is 2-nitroterephthalic acid, and H₂TBIP is 5-tert-butylisophthalic acid). Fluorescence performance testing of complexes 1 and 2 showed excellent green and blue fluorescence properties. Based on this, we further prepared HA/CMCS hydrogels using natural polysaccharides hyaluronic acid (HA) and carboxymethyl chitosan (CMCS) as raw materials and studied their internal structural characteristics using scanning electron microscopy. Using "Duhuo Jisheng Decoction" as a drug model, two metal gel scaffolds loaded with "Duhuo Jisheng Decoction" were prepared, and their potential for treating knee osteoarthritis was evaluated.

Keywords: Coordination polymer; Duhuo jisheng decoction; Hydrogel; Osteoarthritis.