Cell-Derived Allograft Models as a Solution to the Obstacles of Preclinical Studies under Limited Resources: A Systematic Review on Experimental Lung Cancer Animal Models

Isa Mahendra; Ahmad Kurniawan; Muhamad Basit Febrian; Iim Halimah; Asep Rizaludin; Dani Gustaman Syarif

doi:10.2174/0127724328295592240419064719

Cell-Derived Allograft Models as a Solution to the Obstacles of Preclinical Studies under Limited Resources: A Systematic Review on Experimental Lung Cancer Animal Models

Curr Rev Clin Exp Pharmacol. 2024 Apr 24. doi: 10.2174/0127724328295592240419064719. Online ahead of print.

Authors

Isa Mahendra¹, Ahmad Kurniawan¹, Muhamad Basit Febrian¹, Iim Halimah¹, Asep Rizaludin¹, Dani Gustaman Syarif²

Affiliations

¹ Research Center for Radioisotope, Radiopharmaceuticals and Biodosimetry Technology, National Research and Innovation Agency, Serpong, Indonesia.
² Research Center for Radiation Process Technology, National Research and Innovation Agency, Serpong, Indonesia.

PMID: 38659262
DOI: 10.2174/0127724328295592240419064719

Abstract

Background: The use of appropriate animal models for cancer studies is a major challenge, particularly for investigators who lack the resources to maintain and use xenograft animals or genetically engineered mouse models (GEMM). In addition, several countries intending to incorporate these models must conduct importation procedures, posing an additional challenge.

Objective: This review aimed to explore the use of cell-derived allograft or syngeneic models under limited resources. The results can be used by investigators, specifically from low-middle-income countries, to contribute to lung cancer eradication.

Method: A literature search was carried out on various databases, including PubMed, Web of Science, and Scopus. In addition, the publication year of the selected articles was set between 2013 and 2023 with different search components (SC), namely lung cancer (SC1), animal models (SC2), and preclinical studies (SC3).

Results: This systematic review focused on selecting animals, cells, and methods that could be applied to generating allograft-type lung cancer animal models from 101 included articles.

Conclusion: Based on the results, the use of cell-derived allograft models in cancer studies is feasible and relevant, and it provides valuable insights regarding the conditions with limited resources.

Keywords: Lung cancer; allograft; animal model; method..