Equalizing transcallosal inhibition in the mouse anterior cingulate mitigates visuospatial neglect

Abstract

A recent study by Wang and colleagues disentangled a transcallosal inhibitory circuit in mouse anterior cingulate cortex (ACC), which modulates excitatory ipsilateral tonus and contralateral inhibition by exciting contralateral parvalbumin-positive (PV+) interneurons. The authors conclude that the identified circuit mediates interhemispheric balance for visuospatial attention and provides top-down modulation of visual cortices.

Keywords: anterior cingulate; attention; corpus callosum; interhemispheric connection; rodent; vision.