Association between body composition and subsequent cardiovascular diseases among 5-year breast cancer survivors

Ji Soo Kim; Jihun Song; Seulggie Choi; Sung Min Kim; Young Jun Park; Sun Jae Park; Yoosun Cho; Yun Hwan Oh; Seogsong Jeong; Kyae Hyung Kim; Sang Min Park

doi:10.1016/j.numecd.2024.03.018

Association between body composition and subsequent cardiovascular diseases among 5-year breast cancer survivors

Nutr Metab Cardiovasc Dis. 2024 Mar 15:S0939-4753(24)00120-0. doi: 10.1016/j.numecd.2024.03.018. Online ahead of print.

Authors

Ji Soo Kim¹, Jihun Song², Seulggie Choi³, Sung Min Kim², Young Jun Park⁴, Sun Jae Park², Yoosun Cho⁵, Yun Hwan Oh⁶, Seogsong Jeong⁷, Kyae Hyung Kim⁸, Sang Min Park⁹

Affiliations

¹ International Healthcare Center, Seoul National University Hospital, Seoul National University College of Medicine, Seoul, South Korea.
² Department of Biomedical Sciences, Seoul National University Graduate School, Seoul, South Korea.
³ Department of Internal Medicine, Seoul National University Hospital, Seoul, South Korea.
⁴ Medical Research Center, Genomic Medicine Institute, Seoul National University, Seoul, South Korea.
⁵ Total Healthcare Center, Kangbuk Samsung Hospital, Sungkyunkwan University School of Medicine, Seoul, South Korea.
⁶ Department of Family Medicine, Chung-Ang University Gwangmyeong Hospital, Chung-Ang University College of Medicine, Gwangmyeong-si, South Korea.
⁷ Department of Biomedical Informatics, CHA University School of Medicine, Seongnam, South Korea.
⁸ Department of Family Medicine, Seoul National University Hospital, Seoul, South Korea.
⁹ Department of Biomedical Sciences, Seoul National University Graduate School, Seoul, South Korea; Department of Family Medicine, Seoul National University Hospital, Seoul, South Korea. Electronic address: smpark.snuh@gmail.com.

PMID: 38658227
DOI: 10.1016/j.numecd.2024.03.018

Abstract

Background and aims: Cardiovascular disease (CVD) remain one of the leading causes of mortality in breast cancer survivors. This study aimed to investigate the association between body composition and subsequent CVD in breast cancer survivors.

Methods and results: A retrospective cohort study of more than 70 thousand 5-year breast cancer survivors aged 40 years or older was conducted using data from the National Health Insurance Service of South Korea. Based on the percentage of predicted lean body mass (pLBMP), appendicular skeletal muscle mass (pASMP), and body fat mass (pBFMP), which were calculated using prediction equations with anthropometric data and health habits, groups were equally divided into quartiles. The risk of CVD was evaluated using multivariate Cox proportional hazards regression. Compared to those with the lowest pLBMP and pASMP, those with the highest pLBMP and pASMP had a 38% and 42% lower risk of CVD, respectively. In contrast, those with the highest pBFMP had a 57% higher risk of CVD compared to those with the lowest pBFMP. Each 1 % increase in pLBMP and pASMP was associated with a decreased risk of CVD [pLBMP, adjusted hazard ratio (aHR): 0.96, 95% CI 0.94-0.98, p < 0.05; pASMP, aHR: 0.91, 95% CI 0.87-0.95, p < 0.05] while each 1 % increase in pBFMP was associated with the increased risk of CVD (aHR: 1.05, 95% CI 1.03-1.07, p < 0.01).

Conclusion: In this cohort study, a high pLBMP, a high pASMP, and a low pBFMP were associated with a lower risk of CVD.

Keywords: Body composition; Breast cancer survivor; Cardiovascular diseases.

Copyright © 2024 The Italian Diabetes Society, the Italian Society for the Study of Atherosclerosis, the Italian Society of Human Nutrition and the Department of Clinical Medicine and Surgery, Federico II University. Published by Elsevier B.V. All rights reserved.