Herbal remedies in the management of hyperuricemia and gout: A review of in vitro, in vivo and clinical evidences

Mohamad Fawzi Mahomoodally; Kaisavadee Coodian; Muzzammil Hosenally; Gokhan Zengin; Mohammad Ali Shariati; Ashraf N Abdalla; Hassan A Alhazmi; Gulrana Khuwaja; Syam Mohan; Asaad Khalid

doi:10.1002/ptr.8211

Herbal remedies in the management of hyperuricemia and gout: A review of in vitro, in vivo and clinical evidences

Phytother Res. 2024 Apr 24. doi: 10.1002/ptr.8211. Online ahead of print.

Authors

Mohamad Fawzi Mahomoodally^{1

2}, Kaisavadee Coodian³, Muzzammil Hosenally⁴, Gokhan Zengin⁵, Mohammad Ali Shariati⁶, Ashraf N Abdalla⁷, Hassan A Alhazmi^{8

9}, Gulrana Khuwaja⁹, Syam Mohan^{8

10}, Asaad Khalid^{8

11}

Affiliations

¹ Institute of Research and Development, Duy Tan University, Da Nang, Vietnam.
² School of Engineering & Technology, Duy Tan University, Da Nang, Vietnam.
³ Department of Health Sciences, Faculty of Medicine and Health Sciences, University of Mauritius, Réduit, Mauritius.
⁴ Department of Economics and Statistics, Faculty of Social Sciences & Humanities, University of Mauritius, Réduit, Mauritius.
⁵ Department of Biology, Faculty of Science, Selcuk University, Konya, Turkey.
⁶ Semey Branch of the Institute, Kazakh Research Institute of Processing and Food Industry, Almaty, Kazakhstan.
⁷ Department of Pharmacology and Toxicology, College of Pharmacy, Umm Al-Qura University, Makkah, Saudi Arabia.
⁸ Substance Abuse and Toxicology Research Center, Jazan University, Jazan, Saudi Arabia.
⁹ Department of Pharmaceutical Chemistry and Pharmacognosy, College of Pharmacy, Jazan University, Jazan, Saudi Arabia.
¹⁰ School of Health Sciences, University of Petroleum and Energy Studies, Dehradun, India.
¹¹ Medicinal and Aromatic Plants and Traditional Medicine Research Institute, National Center for Research, Khartoum, Sudan.

PMID: 38655878
DOI: 10.1002/ptr.8211

Abstract

Gout, or hyperuricemia is a multifactorial and multi-faceted metabolic disease that is quite difficult to manage and/or treat. Conventional therapies such as non-steroidal anti-inflammatory drugs (NSAIDs) such as allopurinol, corticosteroids and colchicine amongst others, have helped in its management and treatment to some extent. This study aimed to compile and analyze the different herbal remedies used in the management of hyperuricemia and gout. A literature search was conducted from key databases (PubMed, ScienceDirect, Cochrane Library, Google Scholar) using relevant keywords via the PRISMA model. Smilax riparia A.DC. from Traditional Chinese Medicine is used in many countries for its therapeutic effect on lowering serum urate levels. No single study was able to establish the efficacy of a specific traditionally used herb via in vitro, in vivo, and clinical studies. Patients were found to use a panoply of natural remedies, mainly plants to treat hyperuricemia and gout, which have been validated to some extent by in vitro, in vivo, and clinical studies. Nonetheless, further research is needed to better understand the ethnopharmacological relationship of such herbal remedies.

Keywords: dietary supplements; gout; herbal medicine; hyperuricemia.

Publication types

Review