The rapid advancement of Micro-Electro-Mechanical Systems (MEMS) technology has established microfluidics as a pivotal field. This technology marks the onset of a new era in various applications, including drug testing, cell culture, and disease monitoring, underscoring its extensive practicality and potential for future exploration. This research delves into the intricate behavior of particle inertial migration within microchannels, particularly focusing on the impact of different channel structures and Reynolds numbers (Re). Our studies reveal that particles in microchannels with one-sided sharp-cornered microstructures migrate towards the sharp corner at a relative position of 0.4 under low flow rates, and towards the straight wall side at a relative position of 0.8 under high flow rates. The migration pattern of equilibrium positions varies with different arrangements of sharp-corner structures, achieving stability at the channel's center only when the sharp corners are symmetrically arranged on both sides. Our investigation into the shape of microstructures indicates that sharp-cornered structures generate a more stable secondary flow compared to rectangular and semi-circular structures, preventing particle aggregation at the outlet. To address the challenges associated with handling variable cross-section geometries and solid-wall boundaries in dissipative particle dynamics methods effectively, we have developed a dissipative particle dynamics model specifically for analyzing such microchannels. Building upon our previous research, this model introduces a conservative force coefficient for particles within the microstructured region and an interaction zone that only involves repulsive forces, aligning well with experimental outcomes. Through the study of microstructures' geometric shapes, this paper offers guidance for designing microchannels for particle enrichment. Furthermore, the dissipative particle dynamics model established for the particle flow and solid structure interaction within microstructured channels provides insights into the mesoscale dynamics of liquid-solid two-phase flow and particle motion. In conclusion, this paper aims to enhance particle motion sample preparation techniques, thereby broadening the scope of microfluidic applications in the biomedical field.
Keywords: Biomedicine; Microchannel; Particle; Reynolds number.
© 2024 The Authors. Published by Elsevier Ltd.