The functional and molecular roles of p75 neurotrophin receptor (p75NTR) in epilepsy

Areej Turkistani; Hayder M Al-Kuraishy; Ali I Al-Gareeb; Ali K Albuhadily; Omnya Elhussieny; Ammar Al-Farga; Faisal Aqlan; Hebatallah M Saad; Gaber El-Saber Batiha

doi:10.1177/11795735241247810

The functional and molecular roles of p75 neurotrophin receptor (p75^NTR) in epilepsy

J Cent Nerv Syst Dis. 2024 Apr 22:16:11795735241247810. doi: 10.1177/11795735241247810. eCollection 2024.

Authors

Areej Turkistani¹, Hayder M Al-Kuraishy², Ali I Al-Gareeb², Ali K Albuhadily², Omnya Elhussieny³, Ammar Al-Farga⁴, Faisal Aqlan⁵, Hebatallah M Saad⁶, Gaber El-Saber Batiha⁷

Affiliations

¹ Department of pharmacology and toxicology, Collage of Medicine, Taif University, Taif, Kingdom of Saudi.
² Professor in department of clinical pharmacology and medicine, college of medicine, Mustansiriyah University, Baghdad, Iraq.
³ Department of Histology and Cytology, Faculty of Veterinary Medicine, Matrouh University, Marsa Matruh, Egypt.
⁴ Biochemistry Department, College of Sciences, University of Jeddah, Jeddah, Saudia Arbia.
⁵ Department of Chemistry, College of Sciences, Ibb University, Ibb Governorate, Yemen.
⁶ Department of Pathology, Faculty of Veterinary Medicine, Matrouh University, Matrouh, Egypt.
⁷ Department of Pharmacology and Therapeutics, Faculty of Veterinary Medicine, Damanhour University, Damanhour, Egypt.

Abstract

Epilepsy is a chronic neurological disorder manifested by recurring unprovoked seizures resulting from an imbalance in the inhibitory and excitatory neurotransmitters in the brain. The process of epileptogenesis involves a complex interplay between the reduction of inhibitory gamma-aminobutyric acid (GABA) and the enhancement of excitatory glutamate. Pro-BDNF/p75^NTR expression is augmented in both glial cells and neurons following epileptic seizures and status epileptics (SE). Over-expression of p75^NTR is linked with the pathogenesis of epilepsy, and augmentation of pro-BDNF/p75^NTR is implicated in the pathogenesis of epilepsy. However, the precise mechanistic function of p75^NTR in epilepsy has not been completely elucidated. Therefore, this review aimed to revise the mechanistic pathway of p75^NTR in epilepsy.

Keywords: Epilepsy; p75NTR.

Plain language summary

Roles of p75 neurotrophin receptor (p75NTR) in epilepsy: Epilepsy is a chronic neurological disorder manifested by recurring unprovoked seizures resulting from an imbalance in the inhibitory and excitatory neurotransmitters in the brain. The process of epileptogenesis involves a complex interplay between the reduction of inhibitory gamma-aminobutyric acid (GABA) and the enhancement of excitatory glutamate. Pro-BDNF/p75NTR expression is augmented in both glial cells and neurons following epileptic seizures and status epileptics (SE). Over-expression of p75NTR is linked with the pathogenesis of epilepsy, and augmentation of pro-BDNF/p75NTR is implicated in the pathogenesis of epilepsy. However, the precise mechanistic function of p75NTR in epilepsy has not been completely elucidated.

Publication types

Review