Cohort study of patients with advanced cancer: outcomes associated with duration of antibiotic therapy for non-ventilator hospital-acquired pneumonia

Seohyuk Lee; Jemma Benson; Avi Cohen; Vincent Quagliarello; Manisha Juthani-Mehta; Rupak Datta

doi:10.1017/ash.2024.54

Cohort study of patients with advanced cancer: outcomes associated with duration of antibiotic therapy for non-ventilator hospital-acquired pneumonia

Antimicrob Steward Healthc Epidemiol. 2024 Apr 18;4(1):e48. doi: 10.1017/ash.2024.54. eCollection 2024.

Authors

Seohyuk Lee^{1

2}, Jemma Benson³, Avi Cohen², Vincent Quagliarello², Manisha Juthani-Mehta^{2

4}, Rupak Datta^{2

5}

Affiliations

¹ Department of Medicine, Beth Israel Deaconess Medical Center, Boston, MA, USA.
² Section of Infectious Diseases, Yale School of Medicine, New Haven, CT, USA.
³ Section of Infectious Diseases, Boston Medical Center, Boston, MA, USA.
⁴ Department of Epidemiology of Microbial Diseases, Yale School of Public Health, New Haven, CT, USA.
⁵ Hospital Epidemiology and Infection Prevention Program, Veterans Affairs Connecticut Healthcare System, West Haven, CT, USA.

Abstract

In this single-center observational study of 118 older adults with advanced cancer who developed non-ventilator hospital-acquired pneumonia, prolonged antibiotic durations (8-14 and ≥15 vs ≤7 d) were not associated with reduced adjusted odds of 90-day all-cause readmission or death. These data may inform antimicrobial stewardship efforts in palliative care settings.