Energy Expenditure, a New Tool for Monitoring Surgical Stress in Colorectal Oncological Patients: A Prospective, Monocentric Study

Robert Ivascu; Madalina Dutu; Dan Corneci; Cornelia Nitipir

doi:10.7759/cureus.56822

Energy Expenditure, a New Tool for Monitoring Surgical Stress in Colorectal Oncological Patients: A Prospective, Monocentric Study

Cureus. 2024 Mar 24;16(3):e56822. doi: 10.7759/cureus.56822. eCollection 2024 Mar.

Authors

Robert Ivascu¹, Madalina Dutu^{1

2}, Dan Corneci^{1

2}, Cornelia Nitipir^{3

4}

Affiliations

¹ Anesthesia and Critical Care, Dr. Carol Davila University Emergency Central Military Hospital, Bucharest, ROU.
² Anesthesia and Critical Care, Carol Davila University of Medicine and Pharmacy, Bucharest, ROU.
³ Oncology, Elias University Emergency Hospital, Bucharest, ROU.
⁴ Oncology, Carol Davila University of Medicine and Pharmacy, Bucharest, ROU.

Abstract

Background: Surgical stress response in colorectal surgery consists of a neurohormonal and an immunological response and influences oncological outcomes. The intensity of surgical trauma influences mortality, morbidity, and metastasis' occurrence in colorectal neoplasia. Energy expenditure (EE) stands for the body's energy consumed to keep its homeostasis and can be either calculated or measured by direct or indirect calorimetry.

Aim: The present study attempted to evaluate surgical stress response using EE measurement and compare it to the postoperative cortisol dynamic.

Methods: A prospective, monocentric study was conducted over a period of one year in the Anesthesiology Department including 21 patients from whom serum cortisol values were collected in the preoperative period and on the first postoperative day, and EE was measured and recorded every 15 minutes throughout surgery using the indirect calorimetry method. The study compared EE values' dynamic registered 30 minutes after intubation and 30 minutes before extubating (after abdominal closure) to cortisol perioperative dynamic.

Results: We enrolled 21 patients and 84 measurements were recorded, 42 probes of serum cortisol and 42 measurements of EE. The mean value of the first measurement of serum cortisol was 13.60±3.6 µg and the second was 16.21±6.52 µg. The average value of the first EE recording was 1273.9±278 kcal and 1463.4±398.2 kcal of the second recording. The bivariate analysis performed showed a good correlation between cortisol variation and EE's variation (Spearman coefficient=0.666, p<0.001, CI=0.285, 0.865). In nine cases (42.85%), cortisol value at 24 hours reached the baseline or below the baselines preoperative value. In eight cases (38.09%), patients' EE at the end of the surgery was lower than that recorded at the beginning of the surgery.

Conclusions: Intraoperative EE variation correlated well with cortisol perioperative dynamic and stood out in this study as a valuable and accessible predictor of surgical stress in colorectal surgery.

Keywords: cortisol dynamic; energy expenditure; indirect calorimetry; oncological outcome; surgical stress response.