Population-based retrospective cohort study on community-acquired pneumonia hospitalization in children with a ventricular septal defect

Sci Rep. 2024 Apr 23;14(1):9307. doi: 10.1038/s41598-024-59510-9.

Abstract

The cohort consisted of 9400 exposed children diagnosed with ventricular septal defect (VSD). The risk of community-acquired pneumonia (CAP) or asthma with VSD was assessed using the Cox proportional hazard model with an inverse probability of treatment weighting. During a mean follow-up of 6.67 years (starting from 12 months after birth), there were 2100 CAP admission cases among exposed patients (incidence rate: 33.2 per 1000 person-years) and 20,109 CAP admission cases among unexposed children (incidence rate: 29.6 per 1000 person-years), with hazard ration of 1.09 (95% CI 1.04-1.14).

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adolescent
  • Asthma / complications
  • Asthma / epidemiology
  • Child
  • Child, Preschool
  • Community-Acquired Infections* / epidemiology
  • Female
  • Heart Septal Defects, Ventricular* / complications
  • Heart Septal Defects, Ventricular* / epidemiology
  • Hospitalization*
  • Humans
  • Incidence
  • Infant
  • Male
  • Pneumonia* / epidemiology
  • Proportional Hazards Models
  • Retrospective Studies
  • Risk Factors