Concentrations of dehydroepiandrosterone-sulphate (DHEA-S) in people with cystic fibrosis on and off elexacaftor-tezacaftor-ivacaftor

Shadaan Abid; Lauren Shaffer; Andrew Bayat; Minjae Lee; Ashley Keller; Raksha Jain

doi:10.1016/j.jcf.2024.04.007

Concentrations of dehydroepiandrosterone-sulphate (DHEA-S) in people with cystic fibrosis on and off elexacaftor-tezacaftor-ivacaftor

J Cyst Fibros. 2024 Apr 22:S1569-1993(24)00052-3. doi: 10.1016/j.jcf.2024.04.007. Online ahead of print.

Authors

Shadaan Abid¹, Lauren Shaffer², Andrew Bayat¹, Minjae Lee³, Ashley Keller¹, Raksha Jain⁴

Affiliations

¹ Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA.
² Department of Internal Medicine, University of Pennsylvania School of Medicine, Philadelphia, PN 19104, USA.
³ Peter O'Donnell Jr. School of Public Health, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA.
⁴ Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA. Electronic address: raksha.jain@utsouthwestern.edu.

PMID: 38653651
DOI: 10.1016/j.jcf.2024.04.007

Abstract

Background: Levels of sulfated Dehydroepiandrosterone (DHEA-S) are unknown in people with Cystic Fibrosis (pwCF). DHEA-S is reported to have an inverse association with inflammation and warrants evaluation in pwCF.

Methods: We compared differences in DHEA-S and other hormones between pwCF (n = 180) and without CF (n = 180) and DHEA-S association with percent predicted forced expiratory volume in one second (ppFEV1). We also evaluated DHEA-S levels in people with CF on elexacaftor-tezacaftor-ivacaftor (ETI) (n = 145).

Results: PwCF (not on ETI) had lower DHEA-S levels compared to healthy non-CF controls. DHEA-S levels in individuals with CF on ETI were similar to those without CF. Lower DHEA-S levels were associated with lower ppFEV1.

Conclusions: PwCF (not on ETI) have lower levels of DHEA-S than people without CF or people with CF on ETI. Additional studies are needed to investigate the impact of DHEA-S on the health of pwCF and mechanisms involved.

Keywords: Adults; Cystic fibrosis; DHEA; Inflammation; Sex.