African Green Monkeys Maintain Zika Virus Neutralizing Antibodies for at Least 1,427 Days Postinfection

Andrew D Haddow; Stephanie V Trefry; Farooq Nasar; Joshua D Shamblin; M Louise M Pitt

doi:10.4269/ajtmh.23-0521

African Green Monkeys Maintain Zika Virus Neutralizing Antibodies for at Least 1,427 Days Postinfection

Am J Trop Med Hyg. 2024 Apr 23:tpmd230521. doi: 10.4269/ajtmh.23-0521. Online ahead of print.

Authors

Andrew D Haddow^{1

2}, Stephanie V Trefry¹, Farooq Nasar¹, Joshua D Shamblin¹, M Louise M Pitt¹

Affiliations

¹ Virology Division, U.S. Army Medical Research Institute of Infectious Diseases, Frederick, Maryland.
² Department of Molecular and Cellular Biology, Kennesaw State University, Kennesaw, Georgia.

PMID: 38653230
DOI: 10.4269/ajtmh.23-0521

Abstract

We report strong Zika virus (ZIKV) neutralizing antibody responses in African green monkeys (Chlorocebus sabaeus) up to 1,427 days after ZIKV exposure via the subcutaneous, intravaginal, or intrarectal routes. Our results suggest that immunocompetent African green monkeys previously infected with ZIKV are likely protected from reinfection for years, possibly life, and would not contribute to virus amplification during ZIKV epizootics.