Highlight of 2023: Thymic B cells-important players in the establishment of T-cell tolerance

Félix Lombard-Vadnais; Sylvie Lesage

doi:10.1111/imcb.12761

Highlight of 2023: Thymic B cells-important players in the establishment of T-cell tolerance

Immunol Cell Biol. 2024 Apr 22. doi: 10.1111/imcb.12761. Online ahead of print.

Authors

Félix Lombard-Vadnais¹, Sylvie Lesage^{1

2}

Affiliations

¹ Immunologie-oncologie, Centre de recherche de l'Hôpital Maisonneuve-Rosemont, Montréal, QC, Canada.
² Département de microbiologie, infectiologie et immunologie, Université de Montréal, Montréal, QC, Canada.

PMID: 38650472
DOI: 10.1111/imcb.12761

Abstract

In this article for the Highlights of 2023 Series, we discuss four recent articles that investigated thymic B cells, in both mice and humans. These studies provide important novel insights into the biology of this unique B-cell population, from their activation and differentiation to their role in promoting the negative selection of thymocytes and the generation of regulatory T cells.

Keywords: Antibody‐secreting cells; T‐cell tolerance; class switch recombination; negative selection; thymic B cells.