CRISPR/Cas9 nickase mediated signal amplification integrating with the trans-cleavage activity of Cas12a for highly selective and sensitive detection of single base mutations

Mil Med Res. 2024 Apr 23;11(1):25. doi: 10.1186/s40779-024-00530-x.
No abstract available

Keywords: CRISPR-Cas12a; Cas9 nickase; Polymerase; Single base mutations.

Publication types

  • Research Support, Non-U.S. Gov't
  • Letter

MeSH terms

  • Bacterial Proteins / genetics
  • CRISPR-Associated Proteins / genetics
  • CRISPR-Cas Systems*
  • Deoxyribonuclease I
  • Endodeoxyribonucleases / genetics
  • Humans
  • Mutation

Substances

  • CRISPR-Associated Proteins
  • Endodeoxyribonucleases
  • Deoxyribonuclease I
  • Cas12a protein
  • Bacterial Proteins