Oleanane-Type Triterpene Glycosides from Camellia phanii and Their α-Glucosidase Inhibitory Activity

Hoang Thi Tuyet Lan; Vu Thi Xuan; Bui Thi Mai Anh; Nguyen Thi Mai; Nguyen Viet Dung; Bui Huu Tai; Nguyen Thi Minh Hang; Vu Mai Thao; Nguyen Xuan Nhiem

doi:10.1002/cbdv.202400053

Oleanane-Type Triterpene Glycosides from Camellia phanii and Their α-Glucosidase Inhibitory Activity

Chem Biodivers. 2024 Apr 22:e202400053. doi: 10.1002/cbdv.202400053. Online ahead of print.

Authors

Hoang Thi Tuyet Lan¹, Vu Thi Xuan², Bui Thi Mai Anh², Nguyen Thi Mai², Nguyen Viet Dung³, Bui Huu Tai⁴, Nguyen Thi Minh Hang⁵, Vu Mai Thao⁵, Nguyen Xuan Nhiem⁶

Affiliations

¹ University of Transport and Communications, Faculty of Basic Sciences, 3 CauGiay, Hanoi, VIET NAM.
² University of Transport and Communications, Faculty of Basic Sciences, 3 CauGiay, Hanoi, Hanoi, VIET NAM.
³ Vietnam Academy of Science and Technology, Insititute of Marine Biochemistry, 3 CauGiay, Hanoi, Hanoi, VIET NAM.
⁴ Vietnam Academy of Science and Technology, Institute of Marine Biochemistry, 18 Hoang Quoc Viet, Hanoi, 10072, Hanoi, VIET NAM.
⁵ Vietnam Academy of Science and Technology, Institute of Marine Biochemistry, Hoang Quoc Viet, Hanoi, 10072, Hanoi, VIET NAM.
⁶ Institute of Marine Biochemistry, Center for Drug Research and Development, 18 Hoang Quoc Viet, 10072, Hà Nội, VIET NAM.

PMID: 38646830
DOI: 10.1002/cbdv.202400053

Abstract

Three new oleanane-type triterpene saponins, named camphanosides A-C (1-3), along with five known compounds, chikusetsusaponin IVa (4), spinasaponin A 28-O-glucoside (5), (-)-epicatechin (6), (--)-epicatechin 3-O-gallate (7), and (-)-epigallocatechin 3-O-gallate (8) were isolated from the leaves Camellia phanii Hakoda & Ninh. Their structures were established by 1D and 2D-NMR and mass spectral analysis and chemical methods. Moreover, compounds 1-5 were also evaluated for α-glucosidase inhibitory activity. Compounds 1-3 exhibited moderate α-glucosidase inhibitory activity with IC50 values of 230.7±18.0, 251.4±22.7, and 421.4±25.6 μM, respectively.

Keywords: Camellia phanii; camphanoside; oleanane-type saponin; α-glucosidase inhibitory.