Developing soft wearable sensors with high sensitivity, low cost, and a wide monitoring range is crucial for monitoring human health. Despite advances in strain sensor technology, achieving high sensitivity and a wide operating range in a single device remains a major challenge in its design and preparation. Herein, a liquid metal (LM) is innovatively ultrasonically anchored to the gaps and surfaces of thermoplastic polyurethane (TPU) electrospun fibers, and then a conductive pathway is constructed through polypyrrole (PPy) self-polymerization to prepare a composite film. The strain sensor developed by ultrasonic anchoring and original polymerization technology shows a high strain coefficient (GF = 4.36 at 12.5% strain) and a low detection limit (less than 1% strain). Importantly, this sensor can monitor joint motion and subtle skin deformations in real time. In addition, the integration of strain sensors and N95 masks enables real-time monitoring of human respiration.