Clinical prognostic significance of xeroderma pigmentosum group C and IFN‑γ in non‑small cell lung cancer

Yongming Wang; Weiyu Wang; Huaijie Wang; Liya Qin; Meijia Zhang; Yong Zhang; Yubing Wang; Changcheng Hao; Meihua Qu; Gongchao Wang

doi:10.3892/ol.2024.14392

Clinical prognostic significance of xeroderma pigmentosum group C and IFN‑γ in non‑small cell lung cancer

Oncol Lett. 2024 Apr 9;27(6):259. doi: 10.3892/ol.2024.14392. eCollection 2024 Jun.

Authors

Yongming Wang^{1

2}, Weiyu Wang^{2

3}, Huaijie Wang², Liya Qin^{2

4}, Meijia Zhang², Yong Zhang², Yubing Wang⁴, Changcheng Hao², Meihua Qu^{2

4}, Gongchao Wang¹

Affiliations

¹ Department of Thoracic Surgery, Shandong Provincial Hospital, Shandong University, Jinan, Shandong 250021, P.R. China.
² Department of Thoracic Surgery, Translational Medical Center, Weifang Second People's Hospital (Weifang Respiratory Disease Hospital), Weifang, Shandong 261041, P.R. China.
³ Department of Otolaryngology, and Head and Neck Surgery, Shandong Provincial ENT Hospital, Jinan, Shandong 250022, P.R. China.
⁴ Biopharmaceutical Laboratory, Key Laboratory of Shandong Province Colleges and Universities, School of Life Sciences and Technology, Weifang Medical University, Weifang, Shandong 261053, P.R. China.

Abstract

Lung cancer is the most common cancer in the world due to its high incidence and recurrence. Genetic instability is one of the main factors leading to its occurrence, development and poor prognosis. Decreased xeroderma pigmentosum group C (XPC) expression notably enhances the stem cell properties of lung cancer cells and increases their proliferation and migration. Additionally, patients with lung cancer and low XPC expression had a poor prognosis. The purpose of the present study was to analyze the effect of XPC and IFN-γ on the clinical prognosis of patients with non-small cell lung cancer (NSCLC). Lung adenocarcinoma specimens were collected from a total of 140 patients with NSCLC. Additionally, from these 140 patients, 48 paracarcinoma tissue specimens were also collected, which were later used to construct tissue microarrays. The expression of XPC and IFN-γ in cancer tissues and in paraneoplastic tissues was detected using immunohistochemistry. The prognosis and overall survival of patients were determined through telephone follow-up. The results showed a positive correlation between expression of XPC and IFN-γ in NSCLC. Additionally, high expression of both markers was associated with a favorable prognosis in patients with NSCLC. The aforementioned findings suggest that the expression of XPC and IFN-γ has prognostic value in clinical practice and is expected to become a marker for clinical application.

Keywords: IFN-γ; clinical significance; non-small cell lung cancer; prognostic; xeroderma pigmentosum group C.

Grants and funding

The present study was supported by the National Natural Science Foundation of China (grant no. 81871892), the Science and Technology Development Project of Weifang (grant nos. 2021YX070 and 2022ZJ1059), the Science and Technology Plan of Shandong Health Committee (grant no. 2019 WSA07011) and the Scientific Project of Weifang Health Commission (grant no. WFWSJK-2022-220).