Craniomaxillofacial development involves a series of highly ordered temporal-spatial cellular differentiation processes in which a variety of cell signaling factors, such as fibroblast growth factors, play important regulatory roles. As a classic fibroblast growth factor, fibroblast growth factor 7 (FGF7) serves a wide range of regulatory functions. Previous studies have demonstrated that FGF7 regulates the proliferation and migration of epithelial cells, protects them, and promotes their repair. Furthermore, recent findings indicate that epithelial cells are not the only ones subjected to the broad and powerful regulatory capacity of FGF7. It has potential effects on skeletal system development as well. In addition, FGF7 plays an important role in the development of craniomaxillofacial organs, such as the palate, the eyes, and the teeth. Nonetheless, the role of FGF7 in oral craniomaxillofacial development needs to be further elucidated. In this paper, we summarized the published research on the role of FGF7 in oral craniomaxillofacial development to demonstrate the overall understanding of FGF7 and its potential functions in oral craniomaxillofacial development.
颅颌面发育是一系列高度有序的时间-空间上的细胞分化过程，多种细胞信号因子如成纤维细胞生长因子等在其中发挥了重要的调控作用。作为经典型成纤维细胞生长因子，成纤维细胞生长因子7（fibroblast growth factor 7, FGF7）具有广泛的调节功能。既往研究已经证实FGF7对上皮细胞有调节其增殖和迁移，保护细胞和促进修复的作用。最近研究进一步指出，FGF7广泛而强大的调控能力不仅仅局限于上皮细胞，其对骨骼系统发育也具有潜在影响。除此之外，FGF7在上颚、眼、牙齿等颅颌面器官的发育中也起着重要作用。然而，在口腔颅颌面发育中FGF7的作用还亟待进一步阐明。本文就目前已有的在口腔颅颌面发育中对FGF7的研究现状进行归纳和总结，展示FGF7在口腔颅颌面发育中的全面认知和其潜在功能。
Keywords: Craniomaxillofacial development; Fibroblast growth factor 7; Review; Skeletal development.
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