Microphysiological systems inspired by leaf venation

Mao Mao; Zijie Meng; Jiankang He; Dichen Li

doi:10.1016/j.tibtech.2024.03.011

Microphysiological systems inspired by leaf venation

Trends Biotechnol. 2024 Apr 19:S0167-7799(24)00092-1. doi: 10.1016/j.tibtech.2024.03.011. Online ahead of print.

Authors

Mao Mao¹, Zijie Meng², Jiankang He³, Dichen Li¹

Affiliations

¹ State Key Laboratory for Manufacturing Systems Engineering, Xi'an Jiaotong University, Xi'an 710049, P.R. China; National Medical Products Administration (NMPA) Key Laboratory for Research and Evaluation of Additive Manufacturing Medical Devices, Xi'an Jiaotong University, Xi'an 710049, P.R. China; National Innovation Platform (Center) for Industry-Education Integration of Medical Technology, Xi'an Jiaotong University, Xi'an 710049, P.R. China.
² State Key Laboratory for Manufacturing Systems Engineering, Xi'an Jiaotong University, Xi'an 710049, P.R. China; National Medical Products Administration (NMPA) Key Laboratory for Research and Evaluation of Additive Manufacturing Medical Devices, Xi'an Jiaotong University, Xi'an 710049, P.R. China; National Innovation Platform (Center) for Industry-Education Integration of Medical Technology, Xi'an Jiaotong University, Xi'an 710049, P.R. China; National Innovation Institute of Additive Manufacturing, Xi'an 710000, P.R. China.
³ State Key Laboratory for Manufacturing Systems Engineering, Xi'an Jiaotong University, Xi'an 710049, P.R. China; National Medical Products Administration (NMPA) Key Laboratory for Research and Evaluation of Additive Manufacturing Medical Devices, Xi'an Jiaotong University, Xi'an 710049, P.R. China; National Innovation Platform (Center) for Industry-Education Integration of Medical Technology, Xi'an Jiaotong University, Xi'an 710049, P.R. China. Electronic address: jiankanghe@mail.xjtu.edu.cn.

PMID: 38643041
DOI: 10.1016/j.tibtech.2024.03.011

Abstract

Nature-inspired microfluidic networks are revolutionizing microphysiological systems, allowing for the precise emulation of human physiology. This article delves into the fabrication techniques of leaf-venation-inspired (LVI) microfluidic networks and explores their transformative applications in organ-on-a-chip and tissue engineering, showcasing their pivotal role in advancing biomedical research.

Keywords: biomimetic microfluidic networks; leaf venation; microphysiological systems; organ-on-a-chip; tissue engineering.