Targeting immune cell glutamyl-prolyl-transfer RNA synthetase 1 (EPRS1) to prevent fibrosis after tubulointerstitial nephritis

Shishir Kumar Patel; Hamid Rabb

doi:10.1016/j.kint.2024.02.007

Targeting immune cell glutamyl-prolyl-transfer RNA synthetase 1 (EPRS1) to prevent fibrosis after tubulointerstitial nephritis

Kidney Int. 2024 May;105(5):924-926. doi: 10.1016/j.kint.2024.02.007.

Authors

Shishir Kumar Patel¹, Hamid Rabb²

Affiliations

¹ Division of Nephrology, Johns Hopkins University, Baltimore, Maryland, USA.
² Division of Nephrology, Johns Hopkins University, Baltimore, Maryland, USA. Electronic address: hrabb1@jhmi.edu.

PMID: 38642990
DOI: 10.1016/j.kint.2024.02.007

Abstract

Glutamyl-prolyl-transfer RNA synthetase 1 is an enzyme that connects glutamic acid and proline to transfer RNA during protein synthesis. In this issue, a study by Kang et al. examined the role of the immune cell glutamyl-prolyl-transfer RNA synthetase 1 in toxin-induced tubulointerstitial nephritis mice. The study demonstrated that blocking glutamyl-prolyl-transfer RNA synthetase 1 may be a therapeutic target to attenuate fibrosis after toxin-induced tubulointerstitial nephritis.

MeSH terms

Amino Acyl-tRNA Synthetases* / genetics
Amino Acyl-tRNA Synthetases* / metabolism
Animals
Fibrosis
Mice
Nephritis, Interstitial* / genetics
Nephritis, Interstitial* / prevention & control

Substances

Amino Acyl-tRNA Synthetases