Prevalence of crimean Congo hemorrhagic fever in Khyber Pakhtunkhwa, Pakistan

Travel Med Infect Dis. 2024 May-Jun:59:102722. doi: 10.1016/j.tmaid.2024.102722. Epub 2024 Apr 18.

Abstract

Background: CCHFV is well recognized as a major public health threat and its prevalence and epidemiological distribution in Pakistan and specifically in KP province is not well documented.

Methods: We used a gold-standard PCR-based diagnostic assay for confirmation of CCHFV among suspected patients. A total of 150 patients were enrolled from June 2022 to September 2022 and their blood samples were collected for PCR confirmation.

Results: The overall positivity rate for CCHFV was 26.67 %, with the virus mostly prevalent in the middle-aged group (21-40 years). In the July of 2022, a significant spike in the prevalence of CCHFV was observed in provincial capital Peshawar with the highest burden (31.57 %).

Conclusion: Our findings indicate the necessity of strengthening CCHFV monitoring programs and intensifying efforts to identify hotspot regions for effective surveillance and control of CCHFV. The months before the Eid-ul-Adha are crucial in the context of CCHFV control.

Keywords: CCHFV; Detection; Hotspots; Khyber Pakhtunkhwa; Prevalence.

MeSH terms

  • Adolescent
  • Adult
  • Child
  • Female
  • Hemorrhagic Fever Virus, Crimean-Congo* / isolation & purification
  • Hemorrhagic Fever, Crimean* / diagnosis
  • Hemorrhagic Fever, Crimean* / epidemiology
  • Humans
  • Male
  • Middle Aged
  • Pakistan / epidemiology
  • Polymerase Chain Reaction
  • Prevalence
  • Young Adult