Measuring synovial thickness on knee MRI in pediatric patients with arthritis: is contrast necessary?

Atsuhiko Handa; M Alejandra Bedoya; Jade Iwasaka-Neder; Patrick R Johnston; Mindy S Lo; Sarah D Bixby

doi:10.1007/s00247-024-05929-1

Measuring synovial thickness on knee MRI in pediatric patients with arthritis: is contrast necessary?

Pediatr Radiol. 2024 Apr 19. doi: 10.1007/s00247-024-05929-1. Online ahead of print.

Authors

Atsuhiko Handa¹, M Alejandra Bedoya², Jade Iwasaka-Neder², Patrick R Johnston², Mindy S Lo³, Sarah D Bixby²

Affiliations

¹ Department of Radiology, Boston Children's Hospital, 300 Longwood Ave, Boston, MA, 02115, USA. atsuhiko.handa@childrens.harvard.edu.
² Department of Radiology, Boston Children's Hospital, 300 Longwood Ave, Boston, MA, 02115, USA.
³ Department of Immunology, Boston Children's Hospital, 300 Longwood Ave, Boston, MA, 02115, USA.

PMID: 38641735
DOI: 10.1007/s00247-024-05929-1

Abstract

Background: The use of contrast-enhanced imaging has long been standard for magnetic resonance imaging (MRI) assessments of synovitis in juvenile idiopathic arthritis (JIA). However, advancements in MRI technology have allowed for reliable identification of synovium without contrast.

Objective: To assess the equivalence of unenhanced MRI with contrast-enhanced MRI in evaluating synovial thickness.

Materials and methods: This is an institutional review board approved, retrospective study performed in a tertiary children's hospital. Pediatric JIA patients under 21 years old were included who underwent knee MRI scans (1.5 T or 3 T) without and with contrast between January 2012 and January 2022. Two radiologists independently measured synovial thickness at 6 knee sites on contrast-enhanced and unenhanced sequences. Numerical measurements and ordinal scores based on juvenile idiopathic arthritis magnetic resonance imaging scoring (JAMRIS) system were recorded, and tests of equivalence were conducted, as well as between-reader and within-reader reliability by concordance correlation coefficient (CCC). All tests were considered significant at the 5% level.

Results: A total of 38 studies from 35 patients (25 females, median age 14 years; interquartile range 7 to 15.7) were included. Equivalence was demonstrated at each of the 6 sites for both continuous measurements (P-values < 0.05) and ordinal scores (P-values < 0.05) based on the average over readers. Within-reader reliability was moderate to high (CCC 0.50-0.89), except for the cruciate ligaments site. Averaged over the 6 sites, reliability between readers was low for unenhanced (CCC 0.47, with 95% CI: [0.41, 0.53]) and moderate for contrast-enhanced (CCC 0.64, with 95% CI: [0.59, 0.69]) sequences.

Conclusion: Unenhanced knee MRI is equivalent to contrast-enhanced MRI in assessment of synovial thickness using conventional MRI sequences. Contrast material helped improve inter-reader reliability.

Keywords: Child; Contrast; Juvenile idiopathic arthritis (JIA); Magnetic resonance imaging (MRI); Synovial thickness; Synovitis.