Impact of baseline yellow plaque assessed by coronary angioscopy on vascular response after stent implantation

Takuya Tsujimura; Isamu Mizote; Takayuki Ishihara; Daisuke Nakamura; Naotaka Okamoto; Tatsuya Shiraki; Naoki Itaya; Mitsuyoshi Takahara; Takaharu Nakayoshi; Osamu Iida; Yosuke Hata; Masami Nishino; Takafumi Ueno; Daisaku Nakatani; Shungo Hikoso; Shinsuke Nanto; Toshiaki Mano; Yasushi Sakata; COLLABORATION Investigators

doi:10.1016/j.jjcc.2024.04.004

Impact of baseline yellow plaque assessed by coronary angioscopy on vascular response after stent implantation

J Cardiol. 2024 Apr 18:S0914-5087(24)00067-4. doi: 10.1016/j.jjcc.2024.04.004. Online ahead of print.

Authors

Takuya Tsujimura¹, Isamu Mizote², Takayuki Ishihara¹, Daisuke Nakamura³, Naotaka Okamoto⁴, Tatsuya Shiraki³, Naoki Itaya⁵, Mitsuyoshi Takahara⁶, Takaharu Nakayoshi⁵, Osamu Iida⁷, Yosuke Hata¹, Masami Nishino⁴, Takafumi Ueno⁸, Daisaku Nakatani³, Shungo Hikoso³, Shinsuke Nanto⁹, Toshiaki Mano¹, Yasushi Sakata³; COLLABORATION Investigators

Affiliations

¹ Kansai Rosai Hospital, Cardiovascular Center, Amagasaki, Japan.
² Department of Cardiovascular Medicine, Osaka University Graduate School of Medicine, Suita, Japan. Electronic address: mizote.isamu.med@osaka-u.ac.jp.
³ Department of Cardiovascular Medicine, Osaka University Graduate School of Medicine, Suita, Japan.
⁴ Division of Cardiology, Osaka Rosai Hospital, Osaka, Japan.
⁵ Division of Cardiovascular Medicine, Kurume University School of Medicine, Kurume, Japan.
⁶ Department of Diabetes Care Medicine, Osaka University Graduate School of Medicine, Suita, Japan.
⁷ Cardiovascular Division, Osaka Police Hospital, Osaka, Japan.
⁸ Division of Cardiology, Marine Hospital, Fukuoka, Japan.
⁹ Department of Cardiovascular Medicine, Nishinomiya Municipal Central Hospital, Nishinomiya, Japan.

PMID: 38641319
DOI: 10.1016/j.jjcc.2024.04.004

Abstract

Background: The relationship between baseline yellow plaque (YP) and vascular response after stent implantation has not been fully investigated.

Methods: This was a sub-analysis of the Collaboration-1 study (multicenter, retrospective, observational study). A total of 88 lesions from 80 patients with chronic coronary syndrome who underwent percutaneous coronary intervention were analyzed. Optical coherence tomography (OCT) and coronary angioscopy (CAS) were serially performed immediately and 11 months after stent implantation. YP was defined as the stented segment with yellow or intensive yellow color assessed by CAS. Neoatherosclerosis was defined as a lipid or calcified neointima assessed by OCT. OCT and CAS findings at 11 months were compared between lesions with baseline YP (YP group) and lesions without baseline YP (Non-YP group).

Results: Baseline YP was detected in 37 lesions (42 %). OCT findings at 11 months showed that the incidence of neoatherosclerosis was significantly higher in the YP group (11 % versus 0 %, p = 0.028) and mean neointimal thickness tended to be lower (104 ± 43 μm versus 120 ± 48 μm, p = 0.098). CAS findings at 11 months demonstrated that the dominant and minimum neointimal coverage grades were significantly lower (p = 0.049 and P = 0.026) and maximum yellow color grade was significantly higher (p < 0.001) in the YP group.

Conclusions: Baseline YP affected the incidence of neoatherosclerosis as well as poor neointimal coverage at 11 months after stent implantation.

Keywords: Angioscopy; Coronary artery disease; Neoatherosclerosis; Optical coherence tomography; Percutaneous coronary intervention.