Chemokine systems in oncology: From microenvironment modulation to nanocarrier innovations

Meng Guan; Shuhan Liu; Yong-Guang Yang; Yanqiu Song; Yuning Zhang; Tianmeng Sun

doi:10.1016/j.ijbiomac.2024.131679

Chemokine systems in oncology: From microenvironment modulation to nanocarrier innovations

Int J Biol Macromol. 2024 Apr 17;268(Pt 1):131679. doi: 10.1016/j.ijbiomac.2024.131679. Online ahead of print.

Authors

Meng Guan¹, Shuhan Liu¹, Yong-Guang Yang², Yanqiu Song³, Yuning Zhang⁴, Tianmeng Sun⁵

Affiliations

¹ Key Laboratory of Organ Regeneration and Transplantation of Ministry of Education, Institute of Immunology, The First Hospital of Jilin University, Changchun, Jilin 130021, China; National-local Joint Engineering Laboratory of Animal Models for Human Diseases, Changchun, Jilin 130021, China; Cancer Center, The First Hospital of Jilin University, Changchun, Jilin 130021, China.
² Key Laboratory of Organ Regeneration and Transplantation of Ministry of Education, Institute of Immunology, The First Hospital of Jilin University, Changchun, Jilin 130021, China; National-local Joint Engineering Laboratory of Animal Models for Human Diseases, Changchun, Jilin 130021, China; International Center of Future Science, Jilin University, Changchun, Jilin 130021, China.
³ Cancer Center, The First Hospital of Jilin University, Changchun, Jilin 130021, China. Electronic address: song_yq@jlu.edu.cn.
⁴ Key Laboratory of Organ Regeneration and Transplantation of Ministry of Education, Institute of Immunology, The First Hospital of Jilin University, Changchun, Jilin 130021, China; National-local Joint Engineering Laboratory of Animal Models for Human Diseases, Changchun, Jilin 130021, China. Electronic address: zhangyuning@jlu.edu.cn.
⁵ Key Laboratory of Organ Regeneration and Transplantation of Ministry of Education, Institute of Immunology, The First Hospital of Jilin University, Changchun, Jilin 130021, China; National-local Joint Engineering Laboratory of Animal Models for Human Diseases, Changchun, Jilin 130021, China; International Center of Future Science, Jilin University, Changchun, Jilin 130021, China; State Key Laboratory of Supramolecular Structure and Materials, Jilin University, Changchun, Jilin 130021, China. Electronic address: tsun41@jlu.edu.cn.

PMID: 38641274
DOI: 10.1016/j.ijbiomac.2024.131679

Abstract

Over the past few decades, significant strides have been made in understanding the pivotal roles that chemokine networks play in tumor biology. These networks, comprising chemokines and their receptors, wield substantial influence over cancer immune regulation and therapeutic outcomes. As a result, targeting these chemokine systems has emerged as a promising avenue for cancer immunotherapy. However, therapies targeting chemokines face significant challenges in solid tumor treatment, due to the complex and fragile of the chemokine networks. A nuanced comprehension of the complicacy and functions of chemokine networks, and their impact on the tumor microenvironment, is essential for optimizing their therapeutic utility in oncology. This review elucidates the ways in which chemokine networks interact with cancer immunity and tumorigenesis. We particularly elaborate on recent innovations in manipulating these networks for cancer treatment. The review also highlights future challenges and explores potential biomaterial strategies for clinical applications.

Keywords: Cancer immunotherapy; Chemokine system; Nanocarrier interventions.

Publication types

Review