Evolution and Antigenic Differentiation of Avian Influenza A(H7N9) Virus, China

Yang Liu; Yuhua Chen; Zhiyi Yang; Yaozhong Lin; Siyuan Fu; Junhong Chen; Lingyu Xu; Tengfei Liu; Beibei Niu; Qiuhong Huang; Haixia Liu; Chaofeng Zheng; Ming Liao; Weixin Jia

doi:10.3201/eid3006.230530

Evolution and Antigenic Differentiation of Avian Influenza A(H7N9) Virus, China

Emerg Infect Dis. 2024 Apr 19;30(6). doi: 10.3201/eid3006.230530. Online ahead of print.

Authors

Yang Liu, Yuhua Chen, Zhiyi Yang, Yaozhong Lin, Siyuan Fu, Junhong Chen, Lingyu Xu, Tengfei Liu, Beibei Niu, Qiuhong Huang, Haixia Liu, Chaofeng Zheng, Ming Liao, Weixin Jia

PMID: 38640498
DOI: 10.3201/eid3006.230530

Abstract

We characterized the evolution and molecular characteristics of avian influenza A(H7N9) viruses isolated in China during 2021-2023. We systematically analyzed the 10-year evolution of the hemagglutinin gene to determine the evolutionary branch. Our results showed recent antigenic drift, providing crucial clues for updating the H7N9 vaccine and disease prevention and control.

Keywords: China; H7N9; Viruses; antigenic drift; avian influenza; evolution; influenza A virus; zoonoses.