An All-rounder for NIR-II Phototheranostics: Well-Tailored 1064 nm Excitable Molecule for Photothermal Combating Orthotopic Breast Cancer

Dingyuan Yan; Zhijun Zhang; Jianyu Zhang; Xue Li; Qian Wu; Yixiong Gui; Jun Zhu; Miaomiao Kang; Xiaohui Chen; Ben Zhong Tang; Dong Wang

doi:10.1002/anie.202401877

An All-rounder for NIR-II Phototheranostics: Well-Tailored 1064 nm Excitable Molecule for Photothermal Combating Orthotopic Breast Cancer

Angew Chem Int Ed Engl. 2024 Apr 18:e202401877. doi: 10.1002/anie.202401877. Online ahead of print.

Authors

Dingyuan Yan¹, Zhijun Zhang², Jianyu Zhang³, Xue Li², Qian Wu², Yixiong Gui², Jun Zhu², Miaomiao Kang², Xiaohui Chen⁴, Ben Zhong Tang³, Dong Wang⁵

Affiliations

¹ Shenzhen University, College of Materials Science and Engineering, 518060, Shenzhen, CHINA.
² Shenzhen University, College of Materials Science and Engineering, CHINA.
³ The Chinese University of Hong Kong - Shenzhen, School of Science and Engineering, CHINA.
⁴ Guangdong Medical University, School of Medical Technology, CHINA.
⁵ Shenzhen University, College of Materials Science and Engineering, NO. 1066, Xueyuan Avenue, Nanshan District, 518000, Shenzhen, CHINA.

PMID: 38637294
DOI: 10.1002/anie.202401877

Abstract

The second near-infrared (NIR-II, 1000-1700 nm) light-activated organic photothermal agent that synchronously enables satisfying NIR-II fluorescence imaging is highly warranted yet rather challenging on the basis of the overwhelming nonradiative decay. Herein, such an agent, namely TPABT-TD, was tactfully designed and constructed via employing benzo[c]thiophene moiety as bulky electron donor/π-bridge and tailoring the peripheral molecular rotors. Benefitting from its high electron donor-acceptor strength and finely modulated intramolecular motion, TPABT-TD simultaneously exhibits ultralong absorption in NIR-II region, intense fluorescence emission in the NIR-IIa (1300-1500 nm) region as nanoaggregates, and high photothermal conversion upon 1064 nm laser irradiation. Those intrinsic advantages endow TPABT-TD nanoparticles with prominent fluorescence/photoacoustic/photothermal trimodal imaging-guided NIR-II photothermal therapy against orthotopic 4T1 breast tumor with negligible adverse effect.

Keywords: NIR-II excitation, aggregation-induced emission, cancer phototheranostics, orthotopic tumor elimination.