Objective: To analyze the trends in literature related to oral microbiology and regenerative medicine from 2014 to 2023. By identifying key research countries, institutions, and their collaboration networks, as well as exploring research hotspots and development directions, the study seeks to provide references for researchers and decision-makers in the field of oral microbiology and regenerative medicine, thereby guiding the direction of future research. Methods: Relevant literature was retrieved using the Web of Science Core Collection database, with data processing and analysis conducted using CiteSpace 6.2.R6 software. Time slicing, node type selection, and the application of the g-index (g-index) were used for filtering, analyzing countries, institutions, authors, journals, and keywords. Results: The volume of literature in the field of oral microbiology and regenerative medicine has steadily increased from 2014 to 2023, with the number of publications first exceeding one hundred in 2020 and reaching 134 in 2022, accompanied by a citation frequency of 3 363 times. China and the United States have been at the forefront in terms of the volume of publications, while the United States and Germany lead in terms of intermediary centrality. The research primarily spans disciplines such as oral medicine, interdisciplinary studies, materials science, and immunology. High-frequency keywords include stem cells, scaffold materials, and gut microbiota, while cluster analysis indicates that inflammation, drug delivery, and antimicrobial activity remain consistent research themes. In recent years, the research heat in "tissue regeneration""gut microbiota " and "maxillofacial surgery" has risen, suggesting these may become focal points of future research. Conclusions: Over the past decade, the volume of literature published in the fields of oral microbiology and regenerative medicine, along with their citation frequencies, has increased annually. The research focus has shifted over time. Understanding the interactions between oral and gut microbiomes is crucial for developing innovative regenerative treatment strategies.
目的： 探讨口腔微生物与再生医学领域相关文献趋势、研究热点和发展方向，为该领域研究者提供有价值的参考和方向。 方法： 利用Web of Science核心合集数据库检索2014—2023年间口腔微生物与再生医学领域相关文献，应用CiteSpace 6.2.R6软件进行数据处理与分析。通过设置时间切片、选择节点类型选择和应用g指数（g-index）进行筛选，对国家、机构、作者、期刊和关键词进行分析。 结果： 2014—2023年期间口腔微生物与再生医学领域文献总量稳步增长，2020年发文量首次突破百篇，到2022年达到134篇，且被引频次高达3 363次。中国和美国的发文量处于前列，但美国和德国文献的中介中心性领先。相关研究主要分布学科领域以口腔医学、交叉学科、材料学和免疫学为主，干细胞、支架材料、肠道微生物为高频关键词，而聚类分析提示炎症、药物递送和抗菌活性为持续的研究主题。近年来，“组织再生”“肠道微生物”和“颌面部手术”的研究热度上升，预示这些内容可能成为未来研究的重点方向。 结论： 近10年来，关于口腔微生物与再生医学领域的文献发文量及其引用频次逐年上升，研究热点随时间推移发生变化。理解口腔微生物与肠道微生物之间的交互作用，对开发新的再生治疗策略具有重要意义。.