Ten cyclopentanoid monoterpenes from the whole plant of Rehmannia piasezkii maxim

Jie Zhou; Guoru Shi; Wanqi Zhang; Ruoyun Chen; Shishan Yu; Dequan Yu; Yanfei Liu

doi:10.1016/j.fitote.2024.105968

Ten cyclopentanoid monoterpenes from the whole plant of Rehmannia piasezkii maxim

Fitoterapia. 2024 Apr 16:175:105968. doi: 10.1016/j.fitote.2024.105968. Online ahead of print.

Authors

Jie Zhou¹, Guoru Shi¹, Wanqi Zhang¹, Ruoyun Chen¹, Shishan Yu², Dequan Yu¹, Yanfei Liu³

Affiliations

¹ State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, China.
² State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, China. Electronic address: yushishan@imm.ac.cn.
³ State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, China. Electronic address: catalpol@imm.ac.cn.

PMID: 38636908
DOI: 10.1016/j.fitote.2024.105968

Abstract

Ten new cyclopentanoid monoterpenes (1-10) were isolated from the whole plant of Rehmannia piasezkii. The structures of these compounds were elucidated based on spectroscopic data analysis. In in-vitro assays, compounds 3, 7, and 9 exhibited weak hepatoprotective activities against APAP-induced HepG2 cell damage. Compound 9 exhibited protective effect on hapassocin carbon tetrachloride model.

Keywords: Cyclopentanoid monoterpenes; Hepatoprotective activity; Rehmannia piasezkii maxim.; Scrophulariaceae.