Anterior cingulate cortex and insomnia: A cingulate-striatum connection

Qi-Yu Chen; Min Zhuo

doi:10.1016/j.neuron.2024.03.016

Anterior cingulate cortex and insomnia: A cingulate-striatum connection

Neuron. 2024 Apr 17;112(8):1202-1204. doi: 10.1016/j.neuron.2024.03.016.

Authors

Qi-Yu Chen¹, Min Zhuo²

Affiliations

¹ School of Basic Medical Sciences, Fujian Medical University, Fuzhou 350108, Fujian Province, China; Zhuomin Institute of Brain Research, Qingdao, Shandong, China.
² Zhuomin Institute of Brain Research, Qingdao, Shandong, China; Department of Physiology, Faculty of Medicine, University of Toronto, Toronto, ON, Canada. Electronic address: min.zhuo@utoronto.ca.

PMID: 38636453
DOI: 10.1016/j.neuron.2024.03.016

Abstract

Insomnia is an important comorbidity of chronic pain. In this issue of Neuron, Li et al. report that chronic-pain-induced insomnia is mediated by the pyramidal neurons in the anterior cingulate cortex and their dopaminergic projections to the dorsal medial striatum.

MeSH terms

Chronic Pain*
Corpus Striatum
Gyrus Cinguli / physiology
Humans
Neostriatum
Pyramidal Cells
Sleep Initiation and Maintenance Disorders*