pHeeling the pHorce

Sang-Min Jeon; Michael J Caterina

doi:10.1016/j.neuron.2024.03.023

pHeeling the pHorce

Neuron. 2024 Apr 17;112(8):1200-1202. doi: 10.1016/j.neuron.2024.03.023.

Authors

Sang-Min Jeon¹, Michael J Caterina²

Affiliations

¹ Department of Neurosurgery, Johns Hopkins School of Medicine, 725 North Wolfe St., Baltimore, MD 21205, USA; Neurosurgery Pain Research Institute, Johns Hopkins School of Medicine, 725 North Wolfe St., Baltimore, MD 21205, USA.
² Department of Neurosurgery, Johns Hopkins School of Medicine, 725 North Wolfe St., Baltimore, MD 21205, USA; Department of Biological Chemistry, Johns Hopkins School of Medicine, 725 North Wolfe St., Baltimore, MD 21205, USA; Department of Neuroscience, Johns Hopkins School of Medicine, 725 North Wolfe St., Baltimore, MD 21205, USA; Neurosurgery Pain Research Institute, Johns Hopkins School of Medicine, 725 North Wolfe St., Baltimore, MD 21205, USA. Electronic address: caterina@jhmi.edu.

PMID: 38636452
DOI: 10.1016/j.neuron.2024.03.023

Abstract

In this issue of Neuron, Yamada et al.¹ show that fast excitatory neurotransmission by protons acting at acid-sensing ion channels (ASICs) mediates mechanical force-evoked signaling at the Merkel cell-neurite complex, contributing to mammalian tactile discrimination.

MeSH terms

Acid Sensing Ion Channels / metabolism
Animals
Mammals / metabolism
Merkel Cells*
Neurites / metabolism
Neurons* / metabolism
Protons
Synaptic Transmission

Substances

Protons
Acid Sensing Ion Channels