Treatment of pediatric intracranial aneurysms: institutional case series and systematic literature review

Michael G Brandel; Jillian H Plonsker; Robert C Rennert; Gautam Produturi; Megana Saripella; Arvin R Wali; Carson McCann; Vijay M Ravindra; David R Santiago-Dieppa; J Scott Pannell; Jeffrey A Steinberg; Alexander A Khalessi; Michael L Levy

doi:10.1007/s00381-024-06384-x

Treatment of pediatric intracranial aneurysms: institutional case series and systematic literature review

Childs Nerv Syst. 2024 Apr 18. doi: 10.1007/s00381-024-06384-x. Online ahead of print.

Affiliations

¹ Department of Neurosurgery, University of California, San Diego-Rady Children's Hospital, San Diego, CA, USA.
² Department of Neurosurgery, University of Utah, 175 North Medical Drive East, Salt Lake City, CA, USA.
³ School of Medicine, University of California, San Diego, CA, USA.
⁴ Department of Neurosurgery, University of California, San Diego-Rady Children's Hospital, San Diego, CA, USA. mlevy@rchsd.org.

PMID: 38635071
DOI: 10.1007/s00381-024-06384-x

Abstract

Introduction: Pediatric intracranial aneurysms (IAs) are rare and have distinct clinical profiles compared to adult IAs. They differ in location, size, morphology, presentation, and treatment strategies. We present our experience with pediatric IAs over an 18-year period using surgical and endovascular treatments and review the literature to identify commonalities in epidemiology, treatment, and outcomes.

Methods: We identified all patients < 20 years old who underwent treatment for IAs at our institution between 2005 and 2020. Medical records and imaging were examined for demographic, clinical, and operative data. A systematic review was performed to identify studies reporting primary outcomes of surgical and endovascular treatment of pediatric IAs. Demographic information, aneurysm characteristics, treatment strategies, and outcomes were collected.

Results: Thirty-three patients underwent treatment for 37 aneurysms over 18 years. The mean age was 11.4 years, ranging from one month to 19 years. There were 21 males (63.6%) and 12 females (36.4%), yielding a male: female ratio of 1.75:1. Twenty-six (70.3%) aneurysms arose from the anterior circulation and 11 (29.7%) arose from the posterior circulation. Aneurysmal rupture occurred in 19 (57.5%) patients, of which 8 (24.2%) were categorized as Hunt-Hess grades IV or V. Aneurysm recurrence or rerupture occurred in five (15.2%) patients, and 5 patients (15.2%) died due to sequelae of their aneurysms. Twenty-one patients (63.6%) had a good outcome (modified Rankin Scale score 0-2) on last follow up. The systematic literature review yielded 48 studies which included 1,482 total aneurysms (611 with endovascular treatment; 656 treated surgically; 215 treated conservatively). Mean aneurysm recurrence rates in the literature were 12.7% and 3.9% for endovascular and surgical treatment, respectively.

Conclusions: Our study provides data on the natural history and longitudinal outcomes for children treated for IAs at a single institution, in addition to our treatment strategies for various aneurysmal morphologies. Despite the high proportion of patients presenting with rupture, good functional outcomes can be achieved for most patients.

Keywords: Cerebral aneurysm; Clipping; Coiling; Endovascular; Flow diversion; Outcomes.