Synthetic soldiers: Turning T cells into immortal warriors

Nicholas P Restifo; Luca Gattinoni

doi:10.1084/jem.20240258

Synthetic soldiers: Turning T cells into immortal warriors

J Exp Med. 2024 May 6;221(5):e20240258. doi: 10.1084/jem.20240258. Epub 2024 Apr 18.

Authors

Nicholas P Restifo^{1

2}, Luca Gattinoni^{3

4

5}

Affiliations

¹ Marble Therapeutics , Boston, MA, USA.
² Cancer Data Science Laboratory, National Cancer Institute, National Institutes of Health , Bethesda, MD, USA.
³ Division of Functional Immune Cell Modulation, Leibniz Institute for Immunotherapy, Regensburg, Germany.
⁴ University of Regensburg , Regensburg, Germany.
⁵ Center for Immunomedicine in Transplantation and Oncology, University Hospital Regensburg , Regensburg, Germany.

PMID: 38634804
PMCID: PMC11032022 (available on 2024-10-18)
DOI: 10.1084/jem.20240258

Abstract

The creation of synthetic T cell states has captivated the field of cell-based therapies. Wang et al. (https://doi.org/10.1084/jem.20232368) describe how disruption of BCOR and ZC3H12A unleashes anti-tumor T cells with unprecedented lifespan and killer instinct. Are we witnessing the birth of immortal super-soldiers in medicine?

MeSH terms

Humans
Longevity
Military Personnel*
T-Lymphocytes