Molecular Epidemiological Study of a Human Brucellosis Outbreak - Weihai City, Shandong Province, China, 2022

China CDC Wkly. 2024 Mar 22;6(12):230-234. doi: 10.46234/ccdcw2024.046.

Abstract

What is already known about this topic?: Brucellosis, mainly caused by Brucella melitensis (B. melitensis), is regarded as a significant zoonotic disease in China. In Weihai, located at the eastern end of the Shandong Peninsula, brucellosis has been in a low epidemic phase for the past five years.

What is added by this report?: This was the initial report of a brucellosis outbreak in the last five years. Strains of B. melitensis bv. 3 from Weihai and other cities showed a close genetic relationship, suggesting a potential common ancestry.

What are the implications for public health practice?: Epidemiological investigations depend on standardized and effective molecular typing methods and analysis tools for public health laboratories to identify and trace outbreaks. Understanding the circulation patterns of livestock in free-range households in heavily affected areas is essential for controlling the spread of brucellosis.

Keywords: Brucellosis; Epidemiological investigations; Molecular typing; Whole genome sequencing.

Grants and funding

Supported by Medical and Health Development Plan of Shandong (2015WS0272), TCM science and technology project of Shandong (Q-2022091)