Acute Effects of Exposure to Fine Particulate Matter and Its Constituents on Sex Hormone Among Postmenopausal Women - Beijing, Tianjin, and Hebei PLADs, China, 2018-2019

Yanlin Tian; Jiaonan Wang; Jianlong Fang; Chen Chen; Feng Zhao; Yi Zhang; Peng Du; Yawei Li; Wanying Shi; Yuanyuan Liu; Enmin Ding; Song Tang; Xu Yue; Xiaoming Shi

doi:10.46234/ccdcw2024.049

Acute Effects of Exposure to Fine Particulate Matter and Its Constituents on Sex Hormone Among Postmenopausal Women - Beijing, Tianjin, and Hebei PLADs, China, 2018-2019

China CDC Wkly. 2024 Mar 29;6(13):249-253. doi: 10.46234/ccdcw2024.049.

Authors

Yanlin Tian^{1

2}, Jiaonan Wang³, Jianlong Fang³, Chen Chen³, Feng Zhao³, Yi Zhang³, Peng Du³, Yawei Li³, Wanying Shi^{3

4}, Yuanyuan Liu³, Enmin Ding³, Song Tang³, Xu Yue², Xiaoming Shi^{3

5}

Affiliations

¹ Chinese Research Academy of Environmental Sciences, Beijing, China.
² Collaborative Innovation Center of Atmospheric Environment and Equipment Technology, Jiangsu Key Laboratory of Atmospheric Environment Monitoring and Pollution Control (AEMPC), Nanjing University of Information Science & Technology, Nanjing City, Jiangsu Province, China.
³ China CDC Key Laboratory of Environment and Population Health, National Institute of Environmental Health, Chinese Center for Disease Control and Prevention, Beijing, China.
⁴ Department of Epidemiology and Health Statistics, School of Public Health, Capital Medical University, and Beijing Municipal Key Laboratory of Clinical Epidemiology, Beijing, China.
⁵ National Key Laboratory of Intelligent Tracking and Forecasting for Infectious Diseases, National Institute of Environmental Health, Chinese Center for Disease Control and Prevention, Beijing, China.

Abstract

What is already known on this topic?: Exposure to fine particulate matter (PM_2.5) was linked to endocrine hormone disruption in the reproductive system. Nonetheless, it was unclear which specific components of PM_2.5 were primarily responsible for these associations.

What is added by this report?: The study presented the initial epidemiological evidence that brief exposure to PM_2.5 can elevate estradiol levels in postmenopausal women. Various particle components had unique effects, with water-soluble ions and specific inorganic elements like Ag, As, Cd, Hg, Ni, Sb, Se, Sn, and Tl potentially playing significant roles in increasing estradiol levels.

What are the implications for public health practice?: The study established that the prevalence of air pollution, along with its specific components, has been recognized as a novel risk factor affecting the balance of sex hormones.

Keywords: PM2.5 components; fine particulate matter; sex hormone.

Copyright and License information: Editorial Office of CCDCW, Chinese Center for Disease Control and Prevention 2024.

Grants and funding

Supported by the National Natural Science Foundation of China (No. 82025030, No. 81941023), the National Key Research and Development Program of China (No. 2022YFC3702700), and the Open Fund provided by the Jiangsu Key Laboratory of Atmospheric Environment Monitoring and Pollution Control (KHK 2104)