Ki-67 index as a predictive marker of meningioma recurrence following surgical resection

Mark Mizrachi; Benjamin Hartley; Shahzaib Saleem; Eric Hintz; Yonah Ziemba; Jianyi Li; Anuj Goenka; Michael Schulder

doi:10.1016/j.jocn.2024.04.015

Ki-67 index as a predictive marker of meningioma recurrence following surgical resection

J Clin Neurosci. 2024 Apr 16:124:15-19. doi: 10.1016/j.jocn.2024.04.015. Online ahead of print.

Authors

Mark Mizrachi¹, Benjamin Hartley², Shahzaib Saleem², Eric Hintz², Yonah Ziemba², Jianyi Li³, Anuj Goenka⁴, Michael Schulder²

Affiliations

¹ Department of Neurosurgery, USA; Donald and Barbara Zucker School of Medicine at Hofstra/Northwell, Hemsptead, NY 11549, USA. Electronic address: mmizrachi@northwell.edu.
² Department of Neurosurgery, USA; Donald and Barbara Zucker School of Medicine at Hofstra/Northwell, Hemsptead, NY 11549, USA.
³ Department of Pathology and Laboratory Medicine, USA; Donald and Barbara Zucker School of Medicine at Hofstra/Northwell, Hemsptead, NY 11549, USA.
⁴ Department of Neurosurgery, USA; Department of Radiation Oncology, USA.

PMID: 38631196
DOI: 10.1016/j.jocn.2024.04.015

Abstract

Background: Meningiomas are the most common primary intracranial tumors in adults. Although benign in a majority of cases, they have a variable clinical course and may recur even after a thorough surgical resection. Ki-67, a nuclear protein involved in cell cycle regulation, has been widely studied as a marker of cellular proliferation in various cancers. However, the prognostic significance of Ki-67 in meningiomas remains controversial. Here, we investigate the Ki-67 index, as a predictive marker of meningioma recurrence following surgical resection and compare it to established prognostic markers such as WHO grade and degree of resection.

Methods: The medical records of 451 patients with previously untreated cranial meningiomas who underwent resections from January 2011 to January 2021 at North Shore University Hospital (NSUH) were reviewed. Collected data included WHO grade, Ki-67 proliferative index, degree of resection - gross (GTR) vs subtotal (STR) - as judged by the surgeon, tumor location, and meningioma recurrence. This study was approved by the NSUH Institutional Review Board IRB 21-1107.

Results: There were 290 patients with grade I, 154 with grade II, and 7 with grade III meningiomas. The average post-resection follow-up period was 4 years, and 82 tumors (18 %) recurred. Higher WHO grades were associated with higher rates of recurrence, with rates of 11.4 %, 27.9 %, and 71.4 % for grades 1, 2, and 3, respectively, and subtotal resection corresponded to a higher rate of recurrence than total resection (34.3 % and 13.4 %, respectively). Higher WHO grades also correlated with higher Ki-67 scores (2.59, 10.01, and 20.71) for grades 1, 2, and 3, respectively. A multivariate logistic regression model identified Ki-67 and degree of resection as independent predictive variables for meningioma recurrence, with Ki-67 specifically predicting recurrence in the WHO grade II subset when analyzed separately for WHO grades I and II.

Conclusion: Our 10-year retrospective study suggests that the Ki-67 index is an important predictive marker for recurrence of intracranial meningiomas following surgical resection, particularly among patients with WHO grade II tumors. Our findings add to a growing body of data that support inclusion of Ki-67 index in the WHO grading criteria for patients with meningiomas.

Keywords: Ki-67 index; Ki-67 score; Ki67 index; Meningioma; Neurosurgery; Proliferation marker; Tumor recurrence.