Lipid-Lowering Meroterpenoids Penihemeroterpenoids A-F from Penicillium herquei GZU-31-6 via Targeting the AMPK/ACC/SREBP-1c Signaling Pathway

Org Lett. 2024 Apr 26;26(16):3424-3428. doi: 10.1021/acs.orglett.4c00946. Epub 2024 Apr 17.

Abstract

Penihemeroterpenoids A-C, the first meroterpenoids with an unprecedented 6/5/6/5/5/6/5 heptacyclic ring system, together with precursors penihemeroterpenoids D-F, were co-isolated from the fungus Penicillium herquei GZU-31-6. Among them, penihemeroterpenoids C-F exhibited lipid-lowering effects comparable to those of the positive control simvastatin by the activation of the AMPK/ACC/SREBP-1c signaling pathway, downregulated the mRNA levels of lipid synthesis genes FAS and PNPLA3, and increased the level of mRNA expression of the lipid export gene MTTP.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • AMP-Activated Protein Kinases* / metabolism
  • Acetyl-CoA Carboxylase / antagonists & inhibitors
  • Acetyl-CoA Carboxylase / metabolism
  • Humans
  • Hypolipidemic Agents / chemistry
  • Hypolipidemic Agents / pharmacology
  • Molecular Structure
  • Penicillium* / chemistry
  • Signal Transduction* / drug effects
  • Sterol Regulatory Element Binding Protein 1* / metabolism
  • Terpenes* / chemistry
  • Terpenes* / pharmacology

Substances

  • Terpenes
  • Sterol Regulatory Element Binding Protein 1
  • AMP-Activated Protein Kinases
  • Acetyl-CoA Carboxylase
  • Hypolipidemic Agents