Abstract
Penihemeroterpenoids A-C, the first meroterpenoids with an unprecedented 6/5/6/5/5/6/5 heptacyclic ring system, together with precursors penihemeroterpenoids D-F, were co-isolated from the fungus Penicillium herquei GZU-31-6. Among them, penihemeroterpenoids C-F exhibited lipid-lowering effects comparable to those of the positive control simvastatin by the activation of the AMPK/ACC/SREBP-1c signaling pathway, downregulated the mRNA levels of lipid synthesis genes FAS and PNPLA3, and increased the level of mRNA expression of the lipid export gene MTTP.
Publication types
-
Research Support, Non-U.S. Gov't
MeSH terms
-
AMP-Activated Protein Kinases* / metabolism
-
Acetyl-CoA Carboxylase / antagonists & inhibitors
-
Acetyl-CoA Carboxylase / metabolism
-
Humans
-
Hypolipidemic Agents / chemistry
-
Hypolipidemic Agents / pharmacology
-
Molecular Structure
-
Penicillium* / chemistry
-
Signal Transduction* / drug effects
-
Sterol Regulatory Element Binding Protein 1* / metabolism
-
Terpenes* / chemistry
-
Terpenes* / pharmacology
Substances
-
Terpenes
-
Sterol Regulatory Element Binding Protein 1
-
AMP-Activated Protein Kinases
-
Acetyl-CoA Carboxylase
-
Hypolipidemic Agents