A prospective case series to evaluate subcostal nerve injury with high-resolution ultrasound in posterior retroperitoneoscopic adrenalectomy

Allon van Uitert; Hossein A Chaman-Baz; Selina E I van der Wal; Xiaoye Zhu; Juerd Wijntjes; Henri J L M Timmers; J Alfred Witjes; Nens van Alfen; Johan F Langenhuijsen

doi:10.1007/s00464-024-10836-5

A prospective case series to evaluate subcostal nerve injury with high-resolution ultrasound in posterior retroperitoneoscopic adrenalectomy

Surg Endosc. 2024 Apr 16. doi: 10.1007/s00464-024-10836-5. Online ahead of print.

Authors

Allon van Uitert¹, Hossein A Chaman-Baz², Selina E I van der Wal³, Xiaoye Zhu², Juerd Wijntjes⁴, Henri J L M Timmers⁵, J Alfred Witjes², Nens van Alfen⁴, Johan F Langenhuijsen²

Affiliations

¹ Department of Urology, Radboud University Medical Center, Geert Grooteplein Zuid 10, 6525 GA, Nijmegen, The Netherlands. allon.vanuitert@radboudumc.nl.
² Department of Urology, Radboud University Medical Center, Geert Grooteplein Zuid 10, 6525 GA, Nijmegen, The Netherlands.
³ Department of Anesthesiology, Pain and Palliative Care, Radboud University Medical Center, Geert Grooteplein Zuid 10, 6525 GA, Nijmegen, The Netherlands.
⁴ Department of Neurology, Clinical Neuromuscular Imaging Group, Donders Center for Neuroscience, Radboud University Medical Centre, Nijmegen, The Netherlands.
⁵ Department of Internal Medicine, Radboud University Medical Center, Geert Grooteplein Zuid 10, 6525 GA, Nijmegen, The Netherlands.

PMID: 38627259
DOI: 10.1007/s00464-024-10836-5

Abstract

Background: Posterior retroperitoneoscopic adrenalectomy has several advantages over transabdominal laparoscopic adrenalectomy regarding operating time, blood loss, postoperative pain, and recovery. However, postoperatively several patients report chronic pain or hypoesthesia. We hypothesized that these symptoms may be the result of damage to the subcostal nerve, because it passes the surgical area.

Methods: A prospective single-center case series was performed in adult patients without preoperative pain or numbness of the abdominal wall who underwent unilateral posterior retroperitoneoscopic adrenalectomy. Patients received pre- and postoperative questionnaires and a high-resolution ultrasound scan of the subcostal nerve and abdominal wall muscles was performed before and directly after surgery. Clinical evaluation at 6 weeks was performed with repeat questionnaires, physical examination, and high-resolution ultrasound. Long-term recovery was evaluated with questionnaires, and photographs from the patients were examined for abdominal wall asymmetry.

Results: A total of 25 patients were included in the study. There were no surgical complications. Preoperative visualization of the subcostal nerve was possible in all patients. At 6 weeks, ultrasound showed nerve damage in 15 patients, with no significant association between nerve damage and postsurgical pain. However, there was a significant association between nerve damage and hypoesthesia (p = 0.01), sensory (p < 0.001), and motor (p < 0.001) dysfunction on physical examination. After a median follow-up of 18 months, 5 patients still experienced either numbness or muscle weakness, and one patient experienced chronic postsurgical pain.

Conclusion: In this exporatory case series the incidence of postoperative damage to the subcostal nerve, both clinically and radiologically, was 60% after posterior retroperitoneoscopic adrenalectomy. There was no association with pain, and the spontaneous recovery rate was high.

Keywords: Adrenalectomy; Case series; High-resolution ultrasound; Nerve damage; Retroperitoneoscopic; Subcostal nerve.